Treatment for CD57-negativeγδT-cell large granular lymphocytic leukemia with pure red cell aplasia:A case report  

作　　者：Ping-Ping Xiao Xu-Yan Chen Zhi-Gao Dong Jin-Mei Huang Qing-Qing Wang Yong-Quan Chen Yi Zhang 

机构地区：[1]Department of Hematology and Rheumatology,The Second Affiliated Hospital of Xiamen Medical College,Xiamen 361021,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2021年第26期7818-7824,共7页世界临床病例杂志

基　　金：Supported by Xiamen Medical and Health Guidance Project,No.3502Z20199137;Fujian Medical and Health Training Project for Young and Middle-aged Backbone Talents,No.2020GGB068;Educational and Scientific Research Program for Young and Middle-Aged Teachers of Fujian Province,No.JAT190838.

摘　　要：BACKGROUND T-cell large granular lymphocytic leukemia(T-LGLL)is a rare type of aplastic anemia with diverse clinical manifestations.Concomitant diseases are often present at the first manifestation.We describe the treatment of a patient with CD57-negativeγδT-LGLL with pure red cell aplasia(PRCA).CASE SUMMARY A 34-year-old woman with a 20-year history of anemia visited our hospital owing to severe dizziness and was admitted.Her condition was diagnosed as CD57-negativeγδT-LGLL with PRCA through bone marrow cytology,bone marrow pathology,bone marrow flow cytometry,bone marrow multiplex polymerase chain reaction combined with fluorescent fragment analysis,and other tests.Treatment with prednisone,methotrexate,and subcutaneous erythropoietin did not significantly change her hemoglobin level.After treatment with oral cyclophosphamide for 3 mo,her hemoglobin level increased to approximately 100 g/L.After 5 mo of treatment,the patient could perform activities of daily living independently.CONCLUSION The treatment of CD57-negativeγδT-LGLL with PRCA with cyclophosphamide helps to improve prognosis.

关 键 词：Large granular lymphocytic leukemia Pure red cell aplasia Aplastic anemia γδT-cell CYCLOPHOSPHAMIDE Case report 

分 类 号：R733.7[医药卫生—肿瘤] R556.5[医药卫生—临床医学]