Emerging targets in cancer drug resistance  

作　　者：Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta 

机构地区：[1]School of Basic and Applied Sciences,Department of Biochemistry and Microbial Sciences,Central University of Punjab,Bathinda 151001,India [2]Department of Urology,Case Western Reserve University,Cleveland,Ohio 44106,USA [3]The Urology Institute,University Hospitals Cleveland Medical Center,Cleveland,Ohio 44106,USA [4]Department of Nutrition,Case Western Reserve University,Cleveland,Ohio 44106,USA [5]Divison of General Medical Sciences,Case Comprehensive Cancer Center,Cleveland,Ohio 44106,USA [6]Department of Urology,Louis Stokes Cleveland Veterans Affairs Medical Center,Cleveland,Ohio 44106,USA.

出　　处：《Cancer Drug Resistance》2019年第2期161-177,共17页癌症耐药（英文）

基　　金：Efforts are supported by the Department of Defense Grants(W81XWH-18-1-0618,W81XWH-15-1-0558);VA Merit Review(1I01BX002494)to Gupta S.Kushwaha PP acknowledges financial support from University Grants Commission,India in the form of CSIR-UGC Senior Research fellowship;Kumar S acknowledges Department of Science and Technology,India,and University Grants Commission,India for providing financial support in the form of DST-SERB Grant[EEQ/2016/000350]and UGC-BSR Research Start-Up-Grant[No.F.30-372/2017(BSR)]respectively.

摘　　要：Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.

关 键 词：Drug resistance transforming growth factor-β Keap1-Nrf2 PI3K-AKT FOXO transcription factors focal adhesion kinases ANNEXINS MIEN1 gene splicing SPHINGOLIPIDS microRNA 

分 类 号：R73[医药卫生—肿瘤]