Exosomal lncRNAs: the newest promising liquid biopsy  

作　　者：Marta Tellez-Gabriel Dominique Heymann 

机构地区：[1]RNA and Molecular Pathology(RAMP)Research Group,Department of Medical Biology,The Artic University of Norway(Tromso),Tromso 9019,Norway [2]INSERM,Institut de Cancérologie de l’Ouest,LabCT,U1232,CRCINA,Universitéde Nantes,Universitéd’Angers,Saint Herblain 44805,France

出　　处：《Cancer Drug Resistance》2019年第4期1002-1017,共16页癌症耐药（英文）

摘　　要：LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding potential.Basal expression of lncRNAs appeared important for various homeostatic processes,like gene imprinting cell differentiation and organogenesis.Moreover,it has been demonstrated that lncRNAs play an important role in tumorigenesis and metastasis.Some lncRNAs were stably detected in exosomes,which are widely found in body fluids.Several studies validated the use of exosomal lncRNAs as minimally invasive diagnostic and prognostic markers in several types of cancers.In addition,exosomal lncRNAs have been associated with drug resistance of tumor cells,suggesting a clinical application in cancer-targeted therapy.Despite the recent increase of studies on exosomal lncRNAs,their clinical significance in cancer diagnosis,prognosis and treatment needs to be fully explored.The methodologies for their detection with high purity and accuracy must be also improved in order to implement their use in clinical routine.This review aims to summarize the main recent technologies available for the isolation of exosomal lncRNAs,their status as a liquid biopsy as well as their future perspectives.

关 键 词：Liquid biopsy long non-coding RNAs EXOSOMES 

分 类 号：R73[医药卫生—肿瘤]