超极化激活的环核苷酸门控阳离子通道与物质成瘾  

Hyperpolarization-activated cyclic nucleotide gated cation channels and substances addiction

作　　者：舒奇钢 叶红明 陆永利[1] 李自成[1] Shu Qigang;Ye Hongming;Lu Yongli;Li Zicheng(Department of Functional Sciences,Medical College of China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院机能学系,宜昌443002

出　　处：《中华行为医学与脑科学杂志》2021年第8期764-768,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(81971248)。

摘　　要：物质成瘾是严重危害人类健康的重要因素之一,目前临床上仍然缺乏有效的治疗药物。研究物质成瘾的机制,寻找新的治疗靶点,研发有效的治疗药物是急需解决的重要课题。超极化激活的环核苷酸门控阳离子通道(hyperpolarization-activated cyclic nucleotide gated cation channels,HCN)参与了许多大脑高级活动,与多种脑疾病的发生发展密切相关,其中HCN通道在物质成瘾中的作用及机制研究正逐步得到重视。近年来,关于物质成瘾的研究证实:在多种精神活性物质成瘾的情况下,多个脑区的HCN通道功能或表达出现异常,但至今尚未能全面了解其机制以及这种变化导致的行为学后果。因此,本文综述HCN通道在成瘾性精神活性物质(如阿片类、可卡因类、大麻类、苯丙胺类、酒精和烟草)成瘾中的神经生物学机制,以期为物质成瘾的机制研究和治疗提供新思路。Substances addiction is one of the important factors that deeply affect human health.At present,there is still lack of effective treatment drugs in the clinic.Exploring mechanisms of substances addiction,finding new therapeutic targets and developing effective therapeutic drugs are important issues to be solved.Hyperpolarization-activated cyclic nucleotide gated cation channels(HCN channels)participate in many advanced brain activities and are closely related to the occurrence and progression of various brain diseases.Among them,the researches on the role and mechanism of HCN channels in substances addiction are gradually gaining attention.Reviewing the researches regarding substances addiction,abnormal function and abnormal expression of HCN channels were observed in many brain regions under the condition of psychoactive substances addiction.However,it has not yet been able to fully understand the mechanism and the behavioral consequences of this change.Therefore,we review the neurobiological mechanisms of HCN channels in substances addiction induced by opioids,cocaine,cannabis,amphetamines,alcohol and tobacco,in order to provide new ideas for the mechanism researches and treatment of substance addiction.

关 键 词：物质成瘾 超极化激活的环核苷酸门控阳离子通道 神经元兴奋性 

分 类 号：R749.6[医药卫生—神经病学与精神病学]