EGFR、EML4-ALK不同基因突变的非小细胞肺癌中医证候分析  

Study on TCM Syndromes of Non-Small Cell Lung Cancer with Different EGFR and EML4-ALK Genes Mutations

作　　者：李丹博 崔青荣[1] 周庆伟[1] LI Danbo;CUI Qingrong;ZHOU Qingwei(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2021年第10期2228-2232,共5页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2017ZY 2063)。

摘　　要：目的:通过对EGFR、EML4-ALK其中一项基因突变且未经治疗的肺癌患者进行中医证候分析,为中医药结合靶向治疗提供依据。方法:收集348例EGFR基因突变患者及101例EML4-ALK基因突变患者中医四诊信息,分别运用系统聚类分析方法得出中医证候。结果:EGFR基因突变患者中医证型为肺肾阴虚证、痰湿血瘀证、肺脾气虚证;EML4-ALK基因突变患者中医证型为痰热壅肺证、阴虚血瘀证、痰湿蕴肺证、肺肾气虚证。结论:EGFR基因突变患者病性表现为虚实夹杂,以正虚为主;EML4-ALK基因突变患者病性表现为虚实夹杂,以邪实为主。Objective:To analyze the TCM syndromes of untreated lung cancer patients with EGFR or EML4-ALK gene mutation,to provide clinical references for the TCM combined with targeted therapy.Methods:The four diagnostic methods information of 348 patients with EGFR gene mutation and 101 patients with EML4-ALK gene mutation were collected,and their TCM syndromes were obtained by using the systematic cluster analysis method respectively.Results:The TCM syndromes of EGFR gene mutation patients were Yin deficiency of Lung and Kidney,phlegm-dampness and Blood stasis,and Qi deficiency of Lung and Spleen.The TCM syndromes of patients with EML4-ALK gene mutation were phlegm-heat obstructing Lung,Yin deficiency and Blood stasis,phlegm-dampness accumulating Lung syndrome,and Lung-Kidney Qi deficiency syndrome.Conclusion:The disease of patients with EGFR gene mutation is characterized by intermingled deficiency and excess,mainly by the presence of healthy qi asthenia.Patients with EML4-ALK gene mutation were characterized by the intermingled deficiency and excessiveness,however,mainly by the presence of excessiveness pathogenic factor.

关 键 词：非小细胞肺癌 EGFR EML4-ALK 基因突变 证候分析 聚类分析 虚实夹杂 

分 类 号：R273.42[医药卫生—中西医结合]