Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis  

作　　者：Chunmeng Ma Jinlong Zhang Yuan Zhang Chen Ma Minrui Ma Fanpeng Ran Xiaoyan Liu Haixia Zhang 

机构地区：[1]College of Chemistry and Chemical Engineering.Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2021年第4期1550-1554,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21575055);the Fundamental Research Funds for the Central Universities(No.561220006)。

摘　　要：As a vital nutrient closely related to the cance r-cells proliferation,phosphate anions have been paid great attention as a promising anticancer agent.Generally,the transport of phosphate anions depends on a protein transport system which is regulated by ion homeostasis regulations.Herein,we designed a reactive anionic nanocarrier based on black phosphorus nanosheets(BPs)and artesunate(ART),which could enter cells through endocytosis to generate phosphate anions,avoiding the regulation of cell homeostasis.The ionic nanocarrier was coated by polydopamine to defend BPs and ART and functionalized by folate(FA)and hyaluronic acid(HA)for targeting factor.With the anchoring groups FA/HA targeted the carrier into cells,polydopamine coating decomposed to expose ART for further generating reactive oxygen species(ROS)in cancer cell microenvironment,providing oxidation conditions.Next,ROS generated by ART makes BPs decompose to phosphate anions with effectively speed,giving rise to the destruction of ion homeostasis to induce necro sis and inhibit the proliferation for cancer cells.In consequence,this research provides novel idea and direction for the ionic carriers and tumor therapeutics.

关 键 词：Phosphate anions carrier Black phosphorus nanosheets ARTESUNATE Phosphate imbalance NECROSIS 

分 类 号：R730.5[医药卫生—肿瘤]