Targeting glioma stem cells via the Hedgehog signaling pathway  

作　　者：Yang Liu Xing Liu Ling‑Chao Chen Wen‑Zhong Du Yu‑Qiong Cui Xing‑Yin Piao Yong‑Li Li Chuan‑Lu Jiang 

机构地区：[1]Department of Neurosurgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang,China

出　　处：《Neuroimmunology and Neuroinflammation》2014年第1期51-59,共9页神经免疫与神经炎症（英文版）

基　　金：This project was supported by the National High Technology Research and Development Program 863(2012AA02A508);national 11th 5 years supporting project(2007BA105B08);Heilongjiang Natural Science key projects(C03030307).

摘　　要：Cancer is one of the leading causes of death worldwide.Gliomas are among the most devastating tumor types,and current clinical therapies are unsatisfactory.Recent reports revealed the importance of glioma-propagating cells in the malignancy of gliomas.These cells,also referred to as glioma stem cells(GSCs),share similarities with neural stem cells(NSCs).The Hedgehog(Hh)signaling pathway controls tissue polarity,patterning maintenance,and maintenance of NSCs during embryonic development.Aberrant activation of the Hh pathway resulting from mutation and deregulation has recently been recognized to cause tumorigenesis in a wide variety of tissues,including gliomas and GSCs.In this review,we explore the role of the Hh signaling pathway in GSCs and its potential as a therapeutic strategy.

关 键 词：Cancer stem cells GLIOMA HEDGEHOG MICRORNA 

分 类 号：R73[医药卫生—肿瘤]