Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation  

作　　者：Yi Guo Tarik Tihan Helen Kim Christopher Hess Michael T.Lawton William L.Young Yuan-Li Zhao Hua Su 

机构地区：[1]Department of Anaesthesia and Perioperative Care,Center for Cerebrovascular Research,San Francisco,CA 94110,USA [2]Department of Pathology,University of California,San Francisco,San Francisco,CA 94110,USA [3]Department of Radiology and Biomedical Imaging,University of California,San Francisco,San Francisco,CA 94110,USA [4]Department of Neurological Surgery,University of California,San Francisco,San Francisco,CA 94110,USA [5]Department of Neurology,University of California,San Francisco,San Francisco,CA 94110,USA [6]Department of Neurosurgery,Affiliated Hospital of Hebei University,Baoding 071000,Hebei,China [7]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 410011,China

出　　处：《Neuroimmunology and Neuroinflammation》2014年第1期147-152,共6页神经免疫与神经炎症（英文版）

基　　金：This study was supported by National Institutes of Health grants:P01 NS44155(WLY and HS),R21 NS083788(HS),R01 NS027713(HS),and R01 NS034949(HK);Hebei Provincial Natural Science Foundation of China grant:H2013201283(YG);National Natural Science Foundation of China grant:No.81271313(YLZ,YG).Conflict of Interest:No.

摘　　要：Aim:To test the hypothesis that lymphocyte infiltration in brain arteriovenous malformation(bAVM)is not associated with iron deposition(indicator of micro-hemorrhage).Methods:Sections of unruptured,previously untreated bAVM specimens(n=19)were stained immunohistochemically for T-lymphocytes(CD3+),B-lymphocytes(CD20+),plasma cells(CD138+)and macrophages(CD68+).Iron deposition was assessed by hematoxylin and eosin and Prussian blue stains.Superficial temporal arteries(STA)were used as control.Results:Both T-lymphocytes and macrophages were present in unruptured,previously untreated bAVM specimens,whereas few B cells and plasma cells were detected.Iron deposition was detected in 8 specimens(42%;95%confidence intervals=20-67%).The samples with iron deposition tended to have more macrophages than those without(666±313 vs.478±174 cells/mm2;P=0.11).T-cells were clustered on the luminal side of the endothelial surface,on the vessel-wall,and in the perivascular regions.There was no correlation between T-lymphocyte load and iron deposition(P=0.88).No macrophages and lymphocytes were detected in STA controls.Conclusion:T-lymphocytes were present in bAVM specimens.Unlike macrophages,the load and location of T-lymphocytes were not associated with iron deposition,suggesting the possibility of an independent cell-mediated immunological mechanism in bAVM pathogenesis.

关 键 词：B-LYMPHOCYTE human brain arteriovenous malformation inflammatory cells micro-hemorrhage T-LYMPHOCYTE 

分 类 号：R73[医药卫生—肿瘤]