Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific immunoglobulins.Exercise alters B cell counts and immunoglobulin l...
Background: RITUXIMAB (RTX) is a chimeric anti-CD20 monoclonal antibody that has initially demonstrated efficacy in patients with B-cell lymphoma. Then, over time, it has demonstrated its efficacy in systemic inflamma...
supported by grants from the Innovative Research Team in the National Natural Science Foundation of China[81721002];the National Science and Technology Major Project[2018ZX10301202].
Background:The mechanisms underlying B-cell hyperactivation in patients with chronic hepatitis B virus(HBV)infection remain largely undefined.The present study assessed the clinical characteristics of the CD39/CD73/ad...
Supported by The National Science Foundation grant MCB-08-42725;National Institutes of Health shared resources Grant No.P30CA047904 to the University of Pittsburgh Cancer Institute;internal funding from the School of Medicine and Department of Immunology
There is a major transformation in gene expression between mature B cells (including follicular, marginal zone, and germinal center cells) and antibody secreting cells (ASCs), i.e. , ASCs, (including plasma blas...
This study was supported by National Institutes of Health grants:P01 NS44155(WLY and HS),R21 NS083788(HS),R01 NS027713(HS),and R01 NS034949(HK);Hebei Provincial Natural Science Foundation of China grant:H2013201283(YG);National Natural Science Foundation of China grant:No.81271313(YLZ,YG).Conflict of Interest:No.
Aim:To test the hypothesis that lymphocyte infiltration in brain arteriovenous malformation(bAVM)is not associated with iron deposition(indicator of micro-hemorrhage).Methods:Sections of unruptured,previously untreate...