Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats  

作　　者：Zhiyong Zeng Guohua Jiang Tianqi Liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi 

机构地区：[1]School of Materials Science and Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China [2]Institute of Smart Biomedical Materials,Zhejiang Sci-Tech University,Hangzhou 310018,China [3]Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China [4]College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China

出　　处：《Bio-Design and Manufacturing》2021年第4期902-911,共10页生物设计与制造（英文）

基　　金：supported by the National Natural Science Foundation of China(No.51873194);the Natural Science Foundation of Zhejiang Province,China(No.LY18E030006).

摘　　要：Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients.In this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats.Gelatin methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding method.The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance.Metformin,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic rats.The drug release period could be significantly prolonged by improving the cross-link density of GelMA-MNs.The results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

关 键 词：MICRONEEDLES METFORMIN Transdermal delivery BIODEGRADABLE GELATIN Hypoglycemic effect 

分 类 号：R943[医药卫生—药剂学]