D-cycloserin,a NMDA-agonist may be a treatment option for anti-NMDAR encephalitis  

作　　者：Hong-Zhi Guan Tie-Kuan Du Jin Xu Xia Lv Hua-Dong Zhu Yi-Cheng Zhu Bin Peng Li-Ying Cui 

机构地区：[1]Department of Neurology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Department of Emergency,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [3]Neuroscience Center,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing100730,China.

出　　处：《Neuroimmunology and Neuroinflammation》2016年第1期189-191,共3页神经免疫与神经炎症（英文版）

摘　　要：Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis is caused by reversible neuron dysfunction associated an autoantibody-mediated decrease of NMDAR in the entire brain.A N-methyl-D-aspartate(NMDA)-agonist treatment for anti-NMDAR encephalitis might have a role considering its specific mechanism.The authors used D-cycloserine,a partial NMDA-agonist in a refractory case with prolonged intensive care unit duration.A 13-year-old female presented with headache,cognitive deterioration,generalized seizures,coma and hypoventilation with required mechanical ventilation.Anti-NMDAR antibodies were identified in cerebrospinal fluid and serum confirming anti-NMDAR encephalitis.The patient was refractory to first-line and second-line immunotherapy and removal of ovary teratoma.D-cycloserine was then administered and her symptoms improved gradually and significantly.This is the first reported case in which D-cycloserine was applied to this disease.D-cycloserine might be a potential option as specific treatment in anti-NMDAR encephalitis.

关 键 词：D-CYCLOSERINE ENCEPHALITIS AUTOANTIBODY N-methyl-D-aspartate receptor AGONIST 

分 类 号：R74[医药卫生—神经病学与精神病学]