急性髓系白血病中DNA甲基化异常及相关调控基因的研究进展  

Advances in abnormal DNA methylation and related regulatory genes in AML

作　　者：王玉姣 张蕊[1] 李艳[1] WANG Yujiao;ZHANG Rui;LI Yan(Department of Hematology,First Hospital of China Medical University,Liaoning Shenyang 110000,China)

机构地区：[1]中国医科大学附属第一医院血液内科,辽宁沈阳110000

出　　处：《现代肿瘤医学》2021年第19期3491-3494,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81600117);辽宁省沈阳市中青年科技创新人才支持计划(编号:RC170525)。

摘　　要：对急性髓系白血病(AML)全基因组测序及表观遗传学调控的研究,发现了一系列调控基因的突变导致DNA甲基化异常,从而导致AML的发生。其中,已有研究证实某些基因突变导致甲基化发生的作用机制,以及相对应的针对性治疗。这里我们讨论AML中导致DNA甲基化异常的调控基因和针对表观遗传调控的治疗进展。From findings about genome sequencing and epigenetic regulation of acute myeloid leukemia(AML),a series of regulatory gene mutations was found leading to related aberrant DNA methylation,which probably lead to the occurrence of AML.Among them,some genes have been extensively studied about their mechanism of function and corresponding targeted therapy.In this paper,we will discuss regulatory genes that lead to aberrant DNA methylation and the treatment of epigenetic regulatory genes.

关 键 词：急性髓系白血病 DNA甲基化 基因突变 去甲基化治疗 

分 类 号：R733.71[医药卫生—肿瘤]