Estrogens and the regulation of glucose metabolism  

作　　者：Marià Alemany 

机构地区：[1]Faculty of Biology,University of Barcelona,Barcelona 08028,Catalonia,Spain

出　　处：《World Journal of Diabetes》2021年第10期1622-1654,共33页世界糖尿病杂志（英文版）（电子版）

摘　　要：The main estrogens:estradiol,estrone,and their acyl-esters have been studied essentially related to their classical estrogenic and pharmacologic functions.However,their main effect in the body is probably the sustained control of core energy metabolism.Estrogen nuclear and membrane receptors show an extraordinary flexibility in the modulation of metabolic responses,and largely explain gender and age differences in energy metabolism:part of these mechanisms is already sufficiently known to justify both.With regard to energy,the estrogen molecular species act essentially through four key functions:(1)Facilitation of insulin secretion and control of glucose availability;(2)Modulation of energy partition,favoring the use of lipid as the main energy substrate when more available than carbohydrates;(3)Functional protection through antioxidant mechanisms;and(4)Central effects(largely through neural modulation)on whole body energy management.Analyzing the different actions of estrone,estradiol and their acyl esters,a tentative classification based on structure/effects has been postulated.Either separately or as a group,estrogens provide a comprehensive explanation that not all their quite diverse actions are related solely to specific molecules.As a group,they constitute a powerful synergic action complex.In consequence,estrogens may be considered wardens of energy homeostasis.

关 键 词：ESTROGENS INSULIN Estrogen receptors Energy metabolism GLUCOSE ANTIOXIDANTS Metabolic syndrome 

分 类 号：R339.6[医药卫生—人体生理学]