Embracing cancer immunotherapy with vital micronutrients  

作　　者：Raymond C-F Yuen Shiu-Ying Tsao 

机构地区：[1]Department of Occupational and Family Medicine,Hosanna Clinic,Singapore 370051,Singapore [2]Department of Clinical Research,Hong Kong SAR Oncology Centre,Hong Kong,China

出　　处：《World Journal of Clinical Oncology》2021年第9期712-724,共13页世界临床肿瘤学杂志（英文版）

摘　　要：Immunotherapy is now commonly prescribed to cancer patients,but autoimmune-related adverse events are considerable.For severe,life-threatening side effects,cessation of therapy seems unavoidable,let alone intensive medical care required for patching up the adverse events.Even without serious adverse events,the response rates are too low and various combinatory regimens have been tried.However,toxicities are also added on,unless the adjuvant agents have remarkably few side effects.Actually,micronutrients are usually taken by a majority of cancer patients as nutritional support or to boost the immune function,let alone hoping to counteract treatment side effects.Recent studies have shown that combinations of micronutrients exert pleiotropic effects in controlling tumor growth and metastasis by modulating the tumor microenvironment,enhancing gut microbiota immune functions,and providing adjunct nutritional support to micronutrient deficient cancer patients.A higher than recommended dietary allowance micronutrient dose is proposed to reduce the toxic free radicals generated as a result of immunotherapy and tumor metabolism.This is not only helpful for managing treatment side effects but also enhancing treatment efficacy.As micronutrient supplementation is also useful to improve patients’quality of life,prolong survival,and sustain compliance to immunotherapy,further investigations are mandatory.

关 键 词：IMMUNOTHERAPY MICRONUTRIENTS Immune-related adverse events VITAMINS Tumor microenvironment IMMUNONUTRITION 

分 类 号：R730.51[医药卫生—肿瘤]