Re-irradiation for high-grade gliomas:Has anything changed?  

作　　者：Sonia García-Cabezas Eleonor Rivin del Campo Juan Solivera-Vela Amalia Palacios-Eito 

机构地区：[1]Department of Radiation Oncology,Reina Sofia University Hospital,Cordoba 14004,Spain [2]Department of Radiation Oncology,Tenon University Hospital,Paris 75020,France [3]Department of Neurosurgery,Reina Sofia University Hospital,Cordoba 14004,Spain

出　　处：《World Journal of Clinical Oncology》2021年第9期767-786,共20页世界临床肿瘤学杂志（英文版）

摘　　要：Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary teams.Improved radiation therapy techniques,new imaging methods,published experience,and a better radiobiological knowledge of brain tissue have positioned re-irradiation(re-RT)as an option for many of these patients.Decisions must be individualized,taking into account the pattern of relapse,previous treatment,and functional status,as well as the patient’s preferences and expected quality of life.Many questions remain unanswered with respect to re-RT:Who is the most appropriate candidate,which dose and fractionation are most effective,how to define the target volume,which imaging technique is best for planning,and what is the optimal timing?This review will focus on describing the most relevant studies that include re-RT as salvage therapy,with the aim of simplifying decision-making and designing the best available therapeutic strategy.

关 键 词：RE-IRRADIATION Recurrent glioma High-grade gliomas GLIOBLASTOMA RADIOSURGERY Stereotactic radiotherapy 

分 类 号：R739.41[医药卫生—肿瘤]