Antipsychotics cardiotoxicity:What's known and what's next  

作　　者：Xiao-Qing Li Xin-Ru Tang Li-Liang Li 

机构地区：[1]Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Psychiatry》2021年第10期736-753,共18页世界精神病学杂志

基　　金：Supported by National Natural Science Foundation of China,No.82070285 and No.81701861.

摘　　要：Chronic use of antipsychotic medications entails a dilemma between the benefit of alleviating psychotic symptoms and the risk of troubling,sometimes lifeshortening adverse effects.Antipsychotic-induced cardiotoxicity is one of the most life-threatening adverse effects that raises widespread concerns.These cardiotoxic effects range from arrhythmia to heart failure in the clinic,with myocarditis/cardiomyopathy,ischemic injuries,and unexplained cardiac lesions as the pathological bases.Multiple mechanisms have been proposed to underlie antipsychotic cardiotoxicity.This review aims to summarize the clinical signs and pathological changes of antipsychotic cardiotoxicity and introduce recent progress in understanding the underlying mechanisms at both the subcellular organelle level and the molecular level.We also provide an up-to-date perspective on future clinical monitoring and therapeutic strategies for antipsychotic cardiotoxicity.We propose that third-generation antipsychotics or drug adjuvant therapy,such as cannabinoid receptor modulators that confer dual benefits—i.e.,alleviating cardiotoxicity and improving metabolic disorders—deserve further clinical evaluation and marketing.

关 键 词：ANTIPSYCHOTICS CARDIOTOXICITY Sudden cardiac deaths Cannabinoid receptor ADRENOCEPTOR 

分 类 号：R969[医药卫生—药理学]