supported by the National Key R&D Program of China(2018YFC1704600);the National Natural Science Foundation of China(81674085,81904309).
Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain unclear.Here,in a rat model...
BACKGROUND When combined with vanadium salts,catecholamines strongly activate glucose uptake in rat and mouse adipocytes.AIM To test whether catecholamines activate glucose transport in human adipocytes.METHODS The up...
Supported by National Natural Science Foundation of China,No.82070285 and No.81701861.
Chronic use of antipsychotic medications entails a dilemma between the benefit of alleviating psychotic symptoms and the risk of troubling,sometimes lifeshortening adverse effects.Antipsychotic-induced cardiotoxicity ...
We thank the staff of animal unit CREFRE, currently headed by Xavier Collet, andespecially its Rangueil satellite for housing wild type and transgenic rodents, andAnne Bouloumié for helpful discussions.
BACKGROUND Benzylamine and methylamine activate glucose uptake in adipocytes.For tyramine,this effect has even been extended to cardiomyocytes.AIM To investigate the effects of catecholamines and other amines on gluco...
Noradrenaline:Within the central nervous system(CNS),the primary source of the catecholamine neurotransmitter noradrenaline is the locus coeruleus(LC)in the pontine tegmentum,with LC neurons projecting to almost all r...
Supported by the Law of Sympathetic Nerve Reaction and Receptor Molecular Response in Relevant Acupoints in Different Myocardial Conditions(No.81373558)
OBJECTIVE: To investigate the effect of electroacupuncture(EA) of acupoints Neiguan(PC 6) and Tianquan(PC 2) on the skin temperature, blood perfusion, and alpha1-and beta2-adrenoreceptor(α1-AR and β2-AR) protein and...
Supported by Financial support from the Fritz Bender Foundation(Munich,to Dascha Deutsch,Frank Entschladen and Kurt S Zanker);from the Nottingham University Hospital Trustees(contributed to the reagent costs)
AIM: To investigate the expression patterns of different adrenoceptor isoforms in ovarian cancer and their association with survival and tumor recurrence. METHODS: The protein expression levels of a1 B, a2 C and b2 ad...
Aim: 7-O-ethylfangchinoline (YH-200) is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant- like action and underlying mechanisms of YH-200 in mice. Methods: Mice weret...
supported by the National Natural Science Foundation of China (81000107,30670835,81071072,31171088);the National Basic Research Program of China (2011CB933500);grants from Key Laboratory of Medical Electrophysiology of Sichuan Province (MEPSCKL2011-01)
Autoimmune activities have been implicated in the pathogenesis of hypertension.High levels of autoantibodies against the second extracellular loop of α1-adrenoceptor(α1-AR autoantibody,α1-AA) are found in patients ...
Aim: To investigate the mechanisms responsible for the protective action of berberine (Ber) against gut damage in endotoxemic mice. Methods: Male BALB/c mice were administered intragastrically with distilled water...