复发抑郁症患者自传体记忆与临床特征相关研究  

The relevant research of autobiographical memory and clinical features in patients with recurrent depression

作　　者：吕振雷[1] 柳艳松 陈潇逸[1] 王妍[2] 贾凤南 张云彪[1] 毛智群[1] LYU Zhen-lei;LIU Yan-song;CHEN Xiao-yi;WANG Yan;JIA Feng-nan;ZHANG Yun-biao;MAO Zhi-qun(Department of Psychiatry,WuXi Mental Hospital,WuXi 214151,China)

机构地区：[1]无锡市精神卫生中心普通精神科,214151 [2]苏州市广济医院临床心理科

出　　处：《临床精神医学杂志》2021年第5期395-398,共4页Journal of Clinical Psychiatry

基　　金：无锡市卫生计生委重大科研项目(Z201605);苏州市科技局项目(SYSD2017140,SS201882,LCZX201719);江苏省卫生健康委科研项目(LGY2019013)。

摘　　要：目的:探讨复发抑郁症患者自传体记忆与临床特征的关系,以及自传体记忆损害是否是抑郁症复发的风险因素。方法:对65例复发抑郁症患者(复发组)以及54例首发抑郁症患者(首发组)采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD-17)及汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评定抑郁与焦虑症状,采用自传体记忆测验评定自传体记忆水平。结果:①与首发组相比,复发组起病年龄更早、病程更长、抑郁症家族史比例更高、认知障碍更严重、概括性记忆更多(P<0.05或P<0.01);②相关分析显示复发组概括性记忆与起病年龄、阳性家族史、认知障碍、迟缓因子呈正相关(r=0.45,0.38,0.39,0.39;P均<0.01);③多因素Logistic回归分析显示概括性记忆是与抑郁症复发相关的危险因素。结论:复发抑郁症患者概括性记忆较多,其与起病年龄、阳性家族史、认知障碍与迟缓因子相关,对预测抑郁症复发具有一定的参考价值。Objective:To explore the autobiographical memory of patients with recurrent depression and its relevance with clinical characteristics,and investigate whether autobiographical memory deficit is a risk factor for recurrent depression.Method:65 recurrent depression patients(the recurrent group)and 54 first-episode depression patients(the first-episode group)were assessed depression and anxiety symptoms with 17-item Hamilton Depression Scale(HAMD-17),Hamilton Anxiety Scale(HAMA)and autobiographical memory with autobiographical memory test.Results:①The recurrent group had earlier age of onset and longer course of depression,more proportion of family history,higher scores of cognitive dysfunction and overgeneral autobiographical memory(OGM)than the first-episode group(P<0.05 or P<0.01).②The correlation analysis showed that OGM score was positively correlated with the age at onset,family history of depression,cognitive disorder and slow factor scores in the recurrent group(r=0.45,0.38,0.39,0.39,respectively;all P<0.01).③The multiple stepwise Logistic regression analysis showed that OGM was risk factor for recurrent depression.Conclusion:The patients with recurrent depression have higher OGM,which is correlated with age of onset,positive family history,cognitive disorder and slow factor.The OGM has a certain role for prediction of recurrent depression.

关 键 词：复发抑郁症 自传体记忆 临床特征 

分 类 号：R749.4[医药卫生—神经病学与精神病学]