Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery  

作　　者：Lili Cai Lihui Li Xihui Chen Lijun Jia 

机构地区：[1]Cancer Institute,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第8期2331-2333,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by the following funds:The Chinese Minister of Science and Technology grant(2016YFA0501800);National Natural Science Foundation of China(Grants 81625018,81802743,and 81820108022);Program of Shanghai Academic/Technology Research Leader(18XD1403800);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056);National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001).

摘　　要：Dear Editor,S phase kinase-associated protein 2(SKP2),a substrate recognition component of the SCFSKP2 ubiquitin ligase complex,plays an oncogenic role in tumorigenesis by targeting a variety of tumor suppressors(e.g.,p21,p27,and p130)for ubiquitina-tion and subsequent degradation.1 As a well-characterized oncoprotein,the aberrant expression and dysregulation of SKP2 are frequently observed in different human cancers.Given its critical role in governing tumorigenesis and progression,SKP2 has emerged as a potential pharmacological target for anticancer therapy.

关 键 词：SKP2 SUPPRESSOR shock 

分 类 号：R730.2[医药卫生—肿瘤]