海洋源生物活性肽的构效关系与作用机理研究进展  

Progress in Understanding the Structure-Activity Relationship and Mechanism of Action of Marine Bioactive Peptides

作　　者：黄沐晨 杨傅佳 陈旭[1,2] 蔡茜茜 陈选[1,2] 吴金鸿 张恒 张军[5] 汪少芸 HUANG Muchen;YANG Fujia;CHEN Xu;CAI Xixi;CHEN Xuan;WU Jinhong;ZHANG Heng;ZHANG Jun;WANG Shaoyun(College of Biological Science and Engineering,Fuzhou University,Fuzhou 350108,China;College of Chemical Engineering,Fuzhou University,Fuzhou 350108,China;School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China;Bankpeptide Biological Technology Co.,Ltd.,Xuancheng 242199,China;Zhongshi Duqing(Shandong)Biotech Co.,Ltd.,Heze 274108,China)

机构地区：[1]福州大学生物科学与工程学院,福建福州350108 [2]福州大学石油化工学院,福建福州350108 [3]上海交通大学农业与生物学院,上海200240 [4]安徽国肽生物科技有限公司,安徽宣城242199 [5]中食都庆(山东)生物技术有限公司,山东菏泽274108

出　　处：《食品科学》2021年第19期271-280,共10页Food Science

基　　金：国家自然科学基金联合基金项目(U1905202);国家自然科学基金面上项目(31771922,31972017);“十三五”国家重点研发计划项目(2018YFD0901006)。

摘　　要：海洋中蕴藏着丰富且独特的生物资源,海洋源蛋白质是开发生物活性肽的良好前体物质,海洋生物活性肽具有来源广泛、高效安全等优势,开发、应用前景广阔。本文综述了海洋源生物活性肽的功能特性,同时从抗氧化肽、抗菌肽、抗冻肽、金属离子螯合肽以及免疫调节肽角度展开详细介绍,阐述了不同海洋源生物活性肽的构效关系和相应的作用机理,提出了海洋源生物活性肽未来研究和发展的趋势,并对海洋源生物活性肽的应用前景进行展望,以期为海洋源生物活性肽的进一步研究提供参考。The sea is rich in unique biological resources.Marine-derived proteins are good precursors for developing bioactive peptides.Marine bioactive peptides have broad development and application prospects with the advantages of wide availability,high efficiency and safety.This paper reviews the functional characteristics of marine bioactive peptides including antioxidant peptides,antimicrobial peptides,antifreeze peptides,metal ion chelating peptides and immunomodulatory peptides.Meanwhile,the structure-activity relationship and mechanism of action of these bioactive peptides are elucidated.Future research and development trends for marine bioactive peptides are discussed together with future application prospects.This paper is expected to provide a reference for further research of marine bioactive peptides.

关 键 词：海洋源生物活性肽 构效关系 作用机理 

分 类 号：O629.72[理学—有机化学]