Insights into the Pathogenesis of Preeclampsia Based on the Features of Placentation and Tumorigenesis  

作　　者：Yun-Qing Zhu Xing-Yu Yan Hua Li Cong Zhang 

机构地区：[1]Shandong Provincial Key Laboratory of Animal Resistance Biology,College of Life Sciences,Shandong Normal University,Ji'nan,Shandong 250014,China [2]School of Medicine,Xiamen University,Xiamen,Fujian 361102,China [3]Department of Gynecology and Obstetrics,Ji'nan Maternity and Child Care Hospital,Ji'nan,Shandong 250000,China [4]Center for Reproductive Medicine,School of Medicine,Ren Ji Hospital,Shanghai Jiao Tong University,Shanghai 200135,China [5]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai 200135,China

出　　处：《Reproductive and Developmental Medicine》2021年第2期97-106,共10页生殖与发育医学（英文版）

基　　金：This study was supported by grants from the National Key R&D Program of China(2019YFA0802600 and 2017YFC1001403);NSFC(31871512 and 31671199)to CZ;Support was also obtained by the Shanghai Commission of Science and Technology(17DZ2271100).

摘　　要：Placentation and tumorigenesis have many common features.Human placentation builds a maternal-fetal connection,circumvents maternal immune rejection of the fetus,and utilizes mechanisms that support tumorigenesis,such as proliferation,invasion,angiogenesis,and immune tolerance.Trophoblasts of the human placenta mimic the behavior of malignant cells,proliferating and invading the uterine decidua until reaching the myometrium and remodeling the spiral arteries that establish a new vascular system and escape the maternal immune response.These processes are under precise temporal and spatial regulation,and their dysregulation is associated with different pregnancy syndromes,including preeclampsia(PE),a pregnancy syndrome that is the leading cause of maternal and perinatal mortality and morbidity.At present,the precise mechanisms underlying the development of PE remain unclear.Here,we summarize and dissect the features between physiological placentation and pathological tumorigenesis to explore the pathogenesis of PE-which we believe to be the result of insufficient placentation,compared to the overaggression of tumorigenesis-to provide novel strategies to prevent and treat PE.

关 键 词：PATHOGENESIS PLACENTATION PREECLAMPSIA TUMORIGENESIS 

分 类 号：R714.244[医药卫生—妇产科学]