Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience  

作　　者：Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski 

机构地区：[1]Department of Nephrology,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Medicine,Division of Respiratory Medicine and Critical Care,Yong Loo Lin School of Medicine and National University Hospital,119228,Singapore [3]Intensive Care Unit,Bach Mai Hospital,Hanoi 100000,Vietnam [4]Department of Medicine,Division of Nephrology,Faculty of Medicine,King Chulalongkorn Memorial Hospital,Bangkok,Thailand [5]Excellence Center for Critical Care Nephrology,King Chulalongkorn Memorial Hospital,Bangkok,Thailand [6]Critical Care Nephrology Research Unit,Chulalongkorn University,Bangkok,Thailand [7]Department of Nephrology,VPS Lakeshore Hospital,Kochi 682040,India [8]Intensive Care Unit,Tuen Mun Hospital,Hong Kong Special Administration Region,China [9]Department of Critical Care Medicine,Quanzhou First Hospital,Quanzhou,Fujian 362000,China [10]Department of Nephrology,Tongji Hospital Affiliated Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [11]Jiangsu Provincial Key Laboratory of Critical Care Medicine,Department of Critical Care Medicine,Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu 210009,China [12]Intensive Care Unit,The Third Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518060,China [13]Department of Anaesthesiology and Intensive Care,Hospital Raja Permaisuri Bainun Ipoh,Malaysia [14]Department of Respiratory and Critical Care Medicine,China-Japan Friendship Hospital,Beijing 100029,China [15]Baxter,Acute Therapies Greater China,Baxter International Inc.,Shanghai 200031,China [16]Baxter World Trade SPRL,Acute Therapies Global,Braine-l’Alleud 1420,Belgium [17]Baxter,Baxter Deutschland GmbH,Unterschleissheim,Germany

出　　处：《Chinese Medical Journal》2021年第18期2258-2260,共3页中华医学杂志（英文版）

摘　　要：To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters.

关 键 词：SEPSIS CYTOKINE ACUTE 

分 类 号：R459.7[医药卫生—急诊医学]