Atroposelective Construction of Axially Chiral Alkene-lndole Scaffolds via Catalytic Enantioselective Addition Reaction of 3-Alkynyl-2-indolylinethanols  

作　　者：Jing-Yi Wang Meng Sun Xian-Yang Yu Yu-Chen Zhang Wei Tan Feng Shi 

机构地区：[1]School of Chemistry and Materials Science,Jiangsu Normal University,Xuzhou,Jiangsu 221116,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2163-2171,共9页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Nos.21772069 and 21831007);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX20_2235);the Natural Science Foundation of JSNU(No.19XSRX013)。

摘　　要：Atroposelective construction of axially chiral alkene-heteroaryl scaffolds is highly desired but challenging.In this work,we established an atroposelective construction of axially chiral alkene-indole scaffolds via the strategy of catalytic enantioselective addition reaction of 3-alkynyl-2-indolylmethanols with bulky nucleophiles.

关 键 词：ATROPISOMERISM Axial chirality Asymmetric catalysis INDOLE Nucleophilic addition 

分 类 号：O626[理学—有机化学] O643.36[理学—化学]