Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor  

作　　者：Katherine Basore 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2021年第8期1455-1455,共1页Sichuan Journal of Physiological Sciences

摘　　要：LDLRAD3 is a recently defined attachment and entry receptor for Venezuelan equine encephalitis virus(VEEV)1,a New World alphavirus that causes severe neurological disease in humans.Here we present near-atomic-resolution cryo-electron microscopy reconstructions of VEEV virus-like particles alone and in a complex with the ectodomains of LDLRAD3.Domain 1 of LDLRAD3 is a low-density lipoprotein receptor type-A module that binds to VEEV by wedging into a cleft created by two adjacent E2-E1 heterodimers in one trimeric spike,and engages domains A and B of E2 and the fusion loop in E1.

关 键 词：ALONE LDLR COMPLEX ENCEPHALITIS VEE 

分 类 号：G63[文化科学—教育学]