南疆地区维吾尔族人群骨量与膳食硫摄入和血清硫化氢的相关性  

Correlation between bone mass,dietary sulfur intake,and serum H_(2)S of the Uygur population in southern Xinjiang

作　　者：李翀[1,2] 方玲娜 孙建华[4] 李晶[4] 李丽[5] 何大伟[6] 郝彦明[1] 周洪斌[7] 陆荣柱 LI Chong;FANG Ling-na;SUN Jiang-hua;LI Jing;LI Li;HE Da-wei;HAO Yan-min;ZHOU Hong-bing;LU Rong-zhu(Department of Orthopaedics,Kunshan Hospital Affiliated to Jiangsu University,Kunshan 215300,Jiangsu,China;Department of Orthopedics,Atushi People s Hospital,Atushi 845350,Xinjiang,China;Department of Endocrinology,Kunshan Hospital Affiliated to Jiangsu University,Kunshan 215300,Jiangsu,China;Department of Orthopedics,the First Affiliated Hospital of Medical College of Shihezi University,Shihezi 832008,Xinjiang,China;Department of Mechanical and Electrical Engineering,Jiangsu United Vocational and Technical College Zhenjiang Branch,Zhenjiang Higher Vocational and Technical School,Zhenjiang 212013,Jiangsu,China;Central laboratory,Kunshan Hospital Affiliated to Jiangsu University,Kunshan 215300,Jiangsu,China;Jiangsu Zhenjiang Customs Comprehensive Technology Center,Zhenjiang 212001,Jiangsu,China;Department of Preventive Medicine and Health Inspection,Medical College of Jiangsu University,Zhenjiang 212013,Jiangsu,China)

机构地区：[1]江苏大学附属昆山医院骨科,江苏昆山215300 [2]阿图什市人民医院骨科,新疆阿图什845350 [3]江苏大学附属昆山医院内分泌科,江苏昆山215300 [4]石河子大学医学院第一附属医院骨科,新疆石河子832008 [5]江苏联合职业技术学院镇江分院镇江高等职业技术学校机电工程系,江苏镇江212013 [6]江苏大学附属昆山医院中心实验室,江苏昆山215300 [7]江苏省镇江海关综合技术中心,江苏镇江212001 [8]江苏大学医学院预防医学与卫生检验系,江苏镇江212013

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2021年第4期360-367,共8页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：新疆克州3123帕米尔领军人才重大课题(KZ2019003);苏州市科技指导项目(sysd2016031);镇江市重点研发计划(社会发展)项目(SH2019015)。

摘　　要：目的观察新疆克州地区维吾尔族人群骨密度和膳食硫摄入、血清硫化氢(hydrogen sulfide,H_(2)S)的关系。方法选取2017年11月至2019年11月新疆阿图什市人民医院172名维吾尔族体检人员,收集一般资料,采用既往食物频数问卷(food frequency questionnaire,FFQ)调查,离子色谱法测定食物硫含量,酶联免疫吸附测定法(enzyme linked immunosorbent assay,ELISA)测定血清H 2S水平,应用超声骨密度仪测定跟骨骨量。结果根据骨量测量结果将人群分为骨量正常组和骨量减少组,骨量正常组的年龄小于骨量减少组[(57.96±8.22)岁vs.(60.84±7.95)岁,P<0.05],每周膳食硫摄入量高于骨量减少组[3202.60(2918.55,3559.50)mg/周vs.2941.92(2389.05,3243.36)mg/周,P<0.001],血清H 2S水平低于骨量减少组[2.96(1.97,3.98)pg/mL vs.6.21(2.82,10.40)pg/mL,P<0.001]。相关分析发现宽带超声衰减(broadband ultrasound attenuation,BUA)与年龄呈负相关(r=-0.252,P=0.001),与每周膳食硫摄入量呈正相关(r=0.225,P=0.003)。多元回归分析结果提示年龄和每周膳食硫摄入量是影响BUA的因素,其中呈负相关的因素为年龄(β=-0.283,P=0.000),呈正相关的因素为每周膳食硫摄入量(β=0.251,P=0.001)。结论膳食硫摄入与骨密度相关,可能具有骨保护作用。Objective To observe the relationship between bone mass(BM) and both dietary sulfur intake and serum hydrogen sulfide(H_(2)) among Uyghur people in Kezhou,Xinjiang.Methods A total of 172 Uyghur medical examiners from Xinjiang Atushi People’s Hospital from November 2017 to November 2019 were selected to collect general data.The food frequency questionnaire(FFQ) survey was used to determine the sulfur content of food by ion chromatography.Enzyme-linked immunosorbent assay(ELISA) was used to measure serum H_(2) levels and an ultrasonic bone scanner was used to determine calcaneal BM.Results According to the results of BM,the population was divided into normal bone mass group and osteopenia group.The age of the normal bone mass group was less than that of the osteopenia group [(57.96±8.22) years vs.(60.84±7.95) years,P<0.05],the weekly dietary sulfur intake was higher than the osteopenia group[3 202.60(2 918.55,3 559.50) mg/week vs.2 941.92(2389.05,3 243.36) mg/week,P < 0.001],and the serum H_(2) level was lower than the osteopenia group [2.96(1.97,3.98) pg/m L vs.6.21(2.82,10.40) pg/m L,P<0.001].Correlation analysis found that the ultrasound amplitude attenuation(BUA) was negatively correlated with age(r=-0.252,P= 0.001) and positively correlated with weekly dietary sulfur intake(r= 0.225,P= 0.003).Multiple regression analysis showed that age and weekly dietary sulfur intake were the factors affecting BUA,with a negative correlation for age(β =-0.283,P = 0.000) and a positive correlation for the weekly dietary sulfur intake(β = 0.251,P =0.001).Conclusion Dietary sulfur intake is related to BM and may help to maintain it.

关 键 词：膳食 硫 硫化氢 骨密度 骨质疏松 

分 类 号：R681[医药卫生—骨科学]