青霉素发酵过程控制系统设计  

Design of Penicillin Fermentation Process Control System

作　　者：项亚南 邓小龙[1] 曹菁[1] 王志伟[1] XIANG Ya-nan;DENG Xiao-long;CAO Jing;WANG Zhi-wei(Jiangsu Vocational College Of Information Technology,Wuxi 214153,China)

机构地区：[1]江苏信息职业技术学院,江苏无锡214153

出　　处：《仪表技术与传感器》2021年第10期75-79,共5页Instrument Technique and Sensor

基　　金：江苏省高等学校自然科学研究面上项目(20KJD510006);江苏省高校优秀科技创新团队基金(2019SJK07);2018年江苏省“青蓝工程”优秀教师团队项目;江苏高校哲学社会科学研究课题(2017SJB0853)。

摘　　要：青霉素生产是典型的间歇过程,它的发酵过程呈现时变性和非线性强的特征,测量量和被控量间之间相互耦合,若操作稍有不当,发酵可能会失败。针对青霉素发酵过程的工艺流程,为了进一步提高青霉素发酵效率并对发酵过程进行实时在线监控,提高发酵过程自动化管理水平,设计出一套青霉素发酵过程自动控制系统。该控制系统从发酵前期准备到发酵实现实施全流程精细化管理,并利用趋势分析方法,通过时间窗口内的参数拟合找出参数在该时段内的趋势变化,实现对菌体生长各阶段的实时监测。该发酵控制系统已经在实际工业中得到应用,效果良好。Penicillin production is a typical batch process.Its fermentation process is time⁃varying and nonlinear.The meas⁃ured quantity and controlled quantity are coupled with each other.If it is operated improperly,the fermentation will fail.According to the process of penicillin fermentation,in order to further improve the efficiency of penicillin fermentation,real⁃time online moni⁃toring of the fermentation process and improve the level of automatic management of the fermentation process,an automatic control system of penicillin fermentation process was designed.The control system realized the fine management from the preparation of fermentation to the whole fermentation process,and used the trend analysis method to find out the trend change of parameters in the period through the parameter fitting in the time window,so as to realize the real⁃time monitoring of each stage of the growth of bacteria.The fermentation control system has been applied in practical industry,and the effect is good.

关 键 词：发酵过程 非线性 控制系统 趋势分析 时间窗口 实时监测 

分 类 号：TP273[自动化与计算机技术—检测技术与自动化装置]