天然椰子油对遗忘型轻度认知功能障碍患者认知功能的改善作用  

Clinical Effect of Natural Coconut Oil on Cognitive Function Improvement in Patients with Amnesia Mild Cognitive Impairment

作　　者：张斌[1] 葛继晖[1] 任梦杨 任军[1] 田龙[1] 白金娟[1] ZHANG Bin;GE Jihui;REN Mengyang;REN Jun;TIAN Long;BAI Jinjuan(Department of Neurology, Zhengzhou People's Hospital, Zhengzhou Henan 450003, China)

机构地区：[1]郑州人民医院神经内科,郑州450003

出　　处：《河南医学高等专科学校学报》2021年第5期513-518,共6页Journal of Henan Medical College

基　　金：河南省医学科技攻关计划基金项目(2018020819);河南省医学科技攻关计划基金项目(2018020822)。

摘　　要：目的探讨服用天然椰子油(virgin coconut oil,VCO)改善遗忘型轻度认知功能障碍(amnestic mild cognitive impairment,aMCI)患者认知功能的效果。方法选取110例aMCI患者,按随机数字表法分为观察组和对照组,各55例。观察组给予VCO治疗,每餐与食物一起服用,或加入食物中食用,每日30 g,对照组正常进食。2组均未进行药物治疗。比较不同时间2组简明精神状态量表(MMSE),蒙特利尔认知评估量表(MoCA)、听觉词语记忆即刻记忆(auditory word memory immediate memory,AWMIM)、听觉词语记忆延迟回忆(auditory word memory delayed recall,AWMIMDR)、数字广度记忆、逆向数字广度记忆、波士顿命名、日常生活活动(ADL)评分及血脂水平变化。结果经过1 a的研究,随着VCO服用时间的延长,观察组患者MMSE、MocA、AWMIM、数字广度记忆、逆向数字记忆、波士顿命名、AWMIMDR逐渐改善,第6个月和第12个月时2组MMSE、MocA、AWMIM、数字广度记忆、逆向数字记忆、波士顿命名比较,差异有统计学意义(P<0.05);2组AWMIMDR和ADL评定比较,差异无统计学意义(P>0.05)。结论aMCI患者服用VCO可以改善MMSE、MocA、AWMIM、数字广度记忆、逆向数字记忆、波士顿命名评分情况,VCO可以一定程度上提高aMCI患者的认知功能。Objective To investigate the effect of virgin coconut oil on improving cognitive function in patients with amnesia mild cognitive impairment(aMCI).Methods A total of 110 patients with amnestic mild cognitive impairment were selected and divided into observation group and control group according to the random number table method,with 55 cases in each group.The observation group was treated with natural coconut oil,take it with food with every meal or add it to food,30 g per day.No drug treatment was given in the two groups.MMSE,MoCA,auditory word memory immediate memory,auditory word memory delayed recall,number span memory,reverse number span memory,Boston naming,daily living ability score and changes in blood lipid levels were compared between two groups at different time.Results After one year of researched,the team fell off 6 cases,control group fell off 2 cases,after statistics analysised,the general data to compared of the two groups had no statistical significance(P<0.05).Through the data statisticsd found that as the changing of natural coconut oil taken time,MMSE,MoCA,hearing words immediate memory,digit span,reverse digital memory,Boston named,delayed auditory words memory memory gradually rised,and MMSE,MoCA,hearing words memory immediate memory,digit span,reverse digital memory,Boston named in 6 months and 12 months data statistically significant(P<0.05),there was no statistical significance between auditory word memory delay memory and daily living ability.Conclusion Natural coconut oil can improve MMSE,MoCA,auditory word memory immediate memory,number breadth memory,reverse number memory,and Boston naming score in amnesia mild cognitive impairment patients,and natural coconut oil can improve cognitive function in amnesia mild cognitive impairment patients to a certain extent.

关 键 词：阿尔茨海默病 遗忘型轻度认知功能障碍 天然椰子油 认知改善 

分 类 号：R749.16[医药卫生—神经病学与精神病学]