肢端无色素性黑素瘤  

Amelanotic acral melanoma

作　　者：冯林[1] 张颖[1] 江阳[1] 卢阳[1] FENG Lin;ZHANG Ying;JIANG Yang;LU Yang(Department of Dermatology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400011,China)

机构地区：[1]重庆市中医院皮肤科,重庆400011

出　　处：《临床皮肤科杂志》2021年第10期609-611,共3页Journal of Clinical Dermatology

摘　　要：报告1例肢端无色素性黑素瘤。患者男,72岁。左足跟部红色结节2个月。皮肤科检查:左足跟部一蚕豆大红色结节,表面溃疡,溃疡面清洁干燥,压痛(+)。皮损组织病理检查:表皮变薄,局部与真皮分界不清,真皮全层及皮下见大量肿瘤细胞,部分呈巢状分布,肿瘤细胞胞质丰富,核大深染,异形性显著,可见脉管,未见溃疡;Breslow厚度约13.6 mm,Clark 5级,核分裂1个/mm^(2);侧切缘及基底切缘可见肿瘤细胞。免疫组化:HMB45、Y染色体性别决定区-盒转录因子10(SOX10)及S-100蛋白均(+);增殖核抗原(Ki-67)(约5%+);波形蛋白(vimentin)、肌酸激酶(CK)、平滑肌肌动蛋白(SMA)及上皮膜抗原(EMA)均(-)。诊断:肢端无色素性黑素瘤。A case of amelanotic acral melanoma is reported.A 72-year-old male presented with a red nodule on the left planta for two months.Physical examination revealed a pea-sized red nodule on the left planta,with clean and dry ulcer on the surface,and tenderness.Histopathological examination showed atrophy of epidermis.Tumor cells has diffused from dermis to subdermis,with some arranged in nests and invasion of vasculature.The tumor cells were composed of rich plasma and atypical nuclei.There was infiltration of a few lymphocytes and no ulcers.Breslow thickness was about 13.6 mm,Clark grade was 5,and mitosis was 1/mm^(2).Tumor cells were found in the lateral and basal margins.Immunohistochemistry showed HMB45(+),SRY-box 10(SOX10)(+),S-100 protein(+),Ki-67(about 5%+),vimentin(-),CK(-),SMA(-)and EMA(-).The diagnosis of amelanotic acral melanoma was established.

关 键 词：黑素瘤 无色素性 肢端 

分 类 号：R739.5[医药卫生—肿瘤]