涎腺导管癌PI3K/AKT/mTOR信号通路中高频突变基因的研究进展  

Research progress on high-frequency mutated genes in the PI3K/AKT/mTOR signalling pathway in salivary duct carcinoma

作　　者：柴国超 张素欣[1] Chai Guochao;Zhang Suxin(Dept.of Stomatology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学第四医院口腔科,石家庄050011

出　　处：《国际口腔医学杂志》2021年第6期731-736,共6页International Journal of Stomatology

基　　金：河北省卫生健康委员会重点科技研究计划(20190695)。

摘　　要：涎腺导管癌(SDC)是涎腺癌的1种侵袭性亚型,复发和转移率高。传统治疗方案是手术切除+淋巴结清扫+辅助放疗,预后较差。近年来,第2代基因测序(NGS)和免疫组织化学(IHC)技术高速发展。借助NGS和IHC技术在SDC中发现多种高频突变基因,这些突变基因以PI3K/AKT/mTOR信号通路为主要靶向信号节点,对SDC产生生物学效应。本文通过对PI3K/AKT/mTOR信号通路及其高频突变基因的介绍进行综述,阐述SDC发生、发展的分子机制。Salivary duct carcinoma(SDC)is an aggressive subtype of salivary gland carcinoma with high recurrence and metastasis rates.The traditional treatment is surgical resection,lymph node dissection and adjuvant radiotherapy,and the prognosis is poor.In recent years,second-generation gene sequencing(NGS)and immunohistochemistry(IHC)technology have developed rapidly.High-frequency mutant genes were found in SDC by NGS and IHC.These mutant genes have biological effects on SDC with the PI3K/AKT/mTOR signalling pathway as the main target signal node.The author intends to summarise the PI3K/AKT/mTOR signalling pathway and its high-frequency mutant genes,as well as elaborate the molecular mechanism of the occurrence and development of SDC.

关 键 词：涎腺导管癌 突变基因 靶点 

分 类 号：R780.2[医药卫生—口腔医学]