CDK4在骨肉瘤中的研究进展  

Research progress of cyclin-dependent kinase 4 in osteosarcoma

作　　者：张兵(综述) 李大鹏[1] 毛良浩(审校) ZHANG Bin;LI Dapeng;MAO Lianghao(Department of Spinal Surgery,Affiliated Hospital of Jiangsu University,Zhenjiang,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院脊柱外科,镇江212001

出　　处：《重庆医学》2021年第21期3746-3749,3754,共5页Chongqing medicine

基　　金：江苏省青年医学重点人才项目(QNRC2016844);江苏省高层次卫生人才“六个一工程”拔尖人才项目(LGY2019089);江苏省研究生实践创新计划(SJCX19_0580);江苏省镇江市重点研发社会发展项目(SH2018036)。

摘　　要：骨肉瘤是未成年人常见的原发性高度恶性骨肿瘤,转移性或复发性患者5年生存率仅为20%。因此,需要研究其转移和复发机制,制订新的治疗方案。细胞周期蛋白依赖性激酶4(CDK4)是丝氨酸/苏氨酸蛋白激酶,参与了细胞周期和转录活性的调节。染色体变异、DNA甲基化、非编码RNA及细胞因子和激素的改变促进了CDK4在骨肉瘤中的表达,并参与了骨肉瘤的发生和发展。利用CDK4在骨肉瘤中特异性表达可有助于临床诊断和分型。该文对骨肉瘤中CDK4作用机制及临床意义的研究进展进行了综述。Osteosarcoma is the most common primary malignant bone tumor in juveniles.The 5-year survival rate is only 20%in the patients with metastasis or recurrence.Therefore,the mechanisms of its metastasis and recurrence needs to be further studied for formulating the new treatment regimen.Cycle-dependent kinase 4 is a serine/threonine(Ser/Thr)protein kinase involved in the regulation of cell cycle and transcriptional activity.Chromosomal variation,DNA methylation,noncoding RNA,and the changes of cytokines and hormones promote the expression of CDK4 in osteosarcoma and contribute to the occurrence and development of osteosarcoma.Using the specific expression of CDK4 in osteosarcoma is conducive to clinical diagnosis and typing.This paper reviews the research progress in the action mechanism and clinical significance of CDK4 in osteosarcoma.

关 键 词：骨肉瘤 细胞周期依赖性蛋白激酶4 基因突变 非编码RNA 靶向治疗 

分 类 号：R738.1[医药卫生—肿瘤]