Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy  

作　　者：Li Huang Xing Yin Jun Chen Ruojing Liu Xiaoyue Xiao Zhiai Hu Yan He Shujuan Zou 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,China [2]The Medical&Nursing School,Chengdu University,Chengdu,610106,China [3]Laboratory for Regenerative Medicine,Tianyou Hospital,Wuhan University of Science and Technology,Wuhan,430064,China [4]Department of Oral and Maxillofacial Surgery,Massachusetts General Hospital and Harvard School of Dental Medicine,Boston,MA,02114,USA

出　　处：《Bioactive Materials》2021年第10期3074-3084,共11页生物活性材料（英文）

基　　金：This work was supported by National Natural Science Foundation of China(Grants No.81801019,81701032,82071150);National Key Research and Development Program of China(Grant No.2018YFC1105703).

摘　　要：Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement,bone resorption,and tooth loss during orthodontic treatment.Promoting bone formation and reducing bone resorption are strategies for controlling these complications.For several decades,the autophagy inducer lithium chloride(LiCl)has been explored for bipolar.In this study,we investigated the autophagy-promoting effect of LiCl on bone remodeling under osteoporotic conditions during tooth movement.Ovariectomy was used to induce osteoporosis status in vivo.The results showed that LiCl rejuvenated autophagy,decreased apoptosis,and promoted bone formation,thus protecting tooth movement in osteoporotic mice.Furthermore,in vitro experiments showed that LiCl reversed the effects of ovariectomy on bone marrow-derived mesenchymal stem cells(BMSCs)extracted from ovariectomized mice,promoting osteogenesis and suppressing apoptosis by positively regulating autophagy.These findings suggest that LiCl can significantly decrease adverse effects of osteoporosis on bone remodeling,and that it has great potential significance in the field of bone formation during tooth movement in osteoporosis patients.

关 键 词：Lithium chloride AUTOPHAGY OSTEOGENESIS Orthodontic tooth movement APOPTOSIS 

分 类 号：R68[医药卫生—骨科学]