Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis  

作　　者：Shu‑Ya Wei Dong‑Bao Hu Meng‑Yuan Xia Ji‑Feng Luo Hui Yan Jing‑Hua Yang Yun‑Song Wang Yue‑Hu Wang 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,School of Chemical Science and Technology,School of Pharmacy,Yunnan University,Kunming 650091,People’s Republic of China [2]Key Laboratory of Economic Plants and Biotechnology,Yunnan Key Laboratory for Wild Plant Resources,and State Key Laboratory of Phytochemistry and Plant Resources in West China,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [3]School of Chemical Biology and Environment,Yuxi Normal University,Yuxi 653100,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第5期545-555,共11页应用天然产物（英文）

摘　　要：One novel spirolactone,aquilarisinolide(1),three new sesquiterpenoids,(2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one(2),(1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one(3),and(4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one(4),together with 13 known compounds(5-17)were isolated from the resinous heartwood of Aquilaria sinensis(Thymelaeaceae).The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra.The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone(CORT)and 1-methyl-4-phenylpyridine ion(MPP+),as well as inhibitory activities against BACE1.Compound 4,5,6-dihydroxy-2-(2-phenylethyl)chromone(5),daphnauranol B(7),6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone(10),isoagarotetrol(14),and 1-hydroxy-1,5-diphenylpentan-3-one(16)showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20μM(P<0.001).Isoagarotetrol(14)showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20μM(P<0.001),while compound 4 showed a moderate activity(P<0.01).The BACE1-inhibitory activities of all tested compounds were very weak with less than 30%inhibition at a concentration of 20μM.

关 键 词：THYMELAEACEAE Aquilaria sinensis SESQUITERPENOIDS 2-(2-phenylethyl)chromones NEUROPROTECTIVE 

分 类 号：Q946[生物学—植物学]