Association between sarcopenic overweight and left ventricular diastolic dysfunction and remodeling in patients with type 2 diabetes  

作　　者：Yong-Ze Zhang Ling-Ning Huang Xi-Mei Shen Jie Lin Feng-Ying Zhao Sun-Jie Yan 

机构地区：[1]Department of Endocrinology,The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian 350005,China [2]Fujian Province Clinical Research Center for Metabolic Diseases,Fuzhou,Fujian 350005,China [3]Diabetes Research Institute of Fujian Province,Fuzhou,Fujian 350005,China [4]Metabolic Diseases Research Institute,The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian 350005,China

出　　处：《Chinese Medical Journal》2021年第20期2489-2491,共3页中华医学杂志（英文版）

基　　金：supported by the Diabetes Fund from Chinese Society of Microcirculation(TW-2018P002);Youth Scientific Research Project of Fujian Health Science and Technology Program(2020QNA057)。

摘　　要：To the Editor:Left ventricular(LV)hypertrophy and diastolic dysfunction are prevalent in patients with type 2 diabetes mellitus(T2DM)[1]and contribute to an increased rate of cardiovascular events.The multifactorial pathological state may be linked to overweight and obesity.However,the definitions of obesity based on body mass index(BMI)resulted in discrepancies in the impact on cardiometabolic risk in different studies.Thus,the exact association between overweight/obesity and diabetic cardiomyopathy is yet controversial.Sarcopenia,age-related decline in muscle mass and strength,also showed an association with cardiovascular disease.[2]Moreover,individuals with high BMI but low muscle mass may not be noticeable but need to be considered.Studies have demonstrated that sarcopenic overweight and obesity are associated with variable cardiometabolic diseases.Diabetes may coexist with sarcopenia or obesity.However,research on the association between sarcopenia and LV diastolic function,LV remodeling,and the association with sarcopenic overweight and obesity is lacking.This study sought to investigate whether sarcopenia and sarcopenic overweight and obesity are independently related to preclinical LV diastolic dysfunction and LV remodeling in patients with T2DM.

关 键 词：DIASTOLIC REMODELING OBESITY 

分 类 号：R587.2[医药卫生—内分泌] R685[医药卫生—内科学]