Disruption of KDM4C-ALDH1 A3 feed-forward loop inhibits sternness,tumorigenesis and chemoresistance of gastric cancer stem cells  

作　　者：Tingyuan Lang Jia Xu Lei Zhou Zhiqi Zhang Xinli Ma Jiayi Gu Jingshu Liu Yunzhe Li Dongyan Ding Jiangfeng Qiu 

机构地区：[1]Ddepartment of Gynecologic Oncology,Chongqing University Cancer Hospital,School of Medicine,Chongqing University,Chongqing,People's Republic of China [2]Department of Gastrointestinal Surgery,Renji Hospital Shanghai Jiao Tong University School of Medicine,Shanghai,People's Republic of China [3]Singapore Eye Research Institute,The Academia,Singapore,Singapore [4]Department of Ophthalmology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore [5]Ophthalmology and Visual Sciences Academia Clinical Program,Duke-NUS Medical School,Singapore,Singapore [6]Department of General Surgery,Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine,Shanghai,People's Republic of China

出　　处：《Signal Transduction and Targeted Therapy》2021年第10期2975-2977,共3页信号转导与靶向治疗（英文）

基　　金：supported by the Science and Technology Commission of Shanghai Municipality Fund(16ZR1420500);the Chongqing Science and Technology Commission(cstc2019jscx-msxmX0174).

摘　　要：Dear Editor,Gastric cancer(GC)is a considerable global health burden;the median survival of advaneed GC is less than 1 year.^(1)Cancer stem cells(CSCs),a small population of cancer cells with stem cell-like properties,are the major cause of treatme nt failure,in eluding GC,2 however,the mechanisms underlying stemness maintenanee of GC stem cells(GCSCs)are still poorly understood.

关 键 词：CANCER Gastric CANCER 

分 类 号：R730.2[医药卫生—肿瘤]