Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy  

作　　者：Chenxu Yan Hongxia Xu Menglan Wu Zijun Zhao Weijun Zhao Jianbin Tang Zhiqian Guo 

机构地区：[1]Key Laboratory for Advanced Materials and Institute of Fine Chemicals,Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai,200237,China [2]Key Laboratory of Biomass Chemical Engineering of Ministry of Education,Center for Bionanoengineering,and Department of Chemical and Biological Engineering,Zhejiang University,Hangzhou,310027,China

出　　处：《Science China Chemistry》2021年第11期2045-2052,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21878087,21908060);the Innovation Program of Shanghai Municipal Education Commission,Shuguang Program(18SG27)。

摘　　要：Uniting dual-modality of fluorescence and photoacoustic(PA)imaging into theranostic nanoprobes is imperative for spatiotemporally tracking of drug delivery,distribution,and release.Herein,we present a rational design strategy of molecularly precise amphiphilic prodrugs BP_(n)-Cy-S-CPT(n=0,5,and 20,refers to the degree of polyethylene glycol(PEG)polymerization;CPT=camptothecin)to tune their self-assembly behaviour,innovatively integrating dual-modal PA and near-infrared(NIR)fluorescence imaging in a single-molecular framework.Among these elaborately designed prodrugs,it is found that only BP_(20)-Cy-S-CPT could form uniform and highly stable self-assemblies,especially in showing synergistically enhanced PA and dualchannel NIR signals.In detail,PA signal is employed to trace the in vivo delivery with high spatial resolution,meanwhile the glutathione(GSH)-triggered dual-channel fluorescence response could real-timely monitor drug distribution and release without"blind spot".The results of in vivo dual-modal PA/NIR imaging have verified that BP_(20)-Cy-S-CPT displayed synergistic targeting(including passive,active,and activatable targeting)for tumor-specific delivery,and thereby executed CPT release in the tumor site.Consequently,our molecularly precise BP_(20)-Cy-S-CPT self-assemblies could make a breakthrough to spatiotemporally track the in vivo drug release profile,expanding the intelligent theranostic toolbox for precise cancer treatment.

关 键 词：fluorescence probe near-infrared fluorescence probe photoacoustic imaging SELF-ASSEMBLY PRODRUG 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]