催产素对男性品行障碍青少年共情能力的影响  

Effect of oxytocin on empathy in male adolescents with conduct disorder

作　　者：明庆森 张静[2] 程长 董戴凤 孙小强[3] 陈文[1] 姚树桥[3] Ming Qingsen;Zhang Jing;Cheng Chang;Dong Daifeng;Sun Xiaoqiang;Chen Wen;Yao Shuqiao(Department of Psychiatry,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Psychiatry,Suzhou Psychiatric Hospital,The Affiliated Guangji Hospital of Soochow University,Suzhou,215137,China;Medical Psychological Center,The Second Xiangya Hospital,Central South University,Changsha,410011,China)

机构地区：[1]苏州大学附属第一医院精神医学科,215006 [2]苏州市广济医院精神科(苏州大学附属广济医院),215137 [3]中南大学湘雅二医院医学心理中心,410011

出　　处：《中华行为医学与脑科学杂志》2021年第10期887-891,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(81471384)。

摘　　要：目的探讨催产素鼻雾剂对男性品行障碍青少年共情能力的影响。方法选取2015年9月至2016年8月于中南大学湘雅二医院心理咨询门诊就诊的品行障碍患者, 采用随机数字表法将其随机纳入催产素组(46例, 催产素鼻雾剂每日给药2次, 每次24 IU, 连续给药2周)与安慰剂组(51例, 给予0.9%氯化钠溶液, 操作方法同催产素组)。干预前后分别采用疼痛共情任务及人际反应指针量表(interpersonal reactivity index, IRI)评估患者共情能力。应用SPSS 20.0软件进行统计分析, 采用重复测量方差分析对比干预前后两组患者的共情能力。结果重复测量方差分析结果显示:疼痛共情任务测评中的针头-痛苦表情维度评分(F=13.86, P<0.001)、IRI总分(F=5.59, P=0.020)及共情关心因子分(F=4.99, P=0.028)的时间×组别交互效应显著。IRI量表观点采择因子分的组别主效应显著(F=4.22, P=0.043)。简单效应分析显示:经2周干预后, 在疼痛共情任务中催产素组患者的针头-痛苦表情评分明显高于基线时评分(t=-2.08, P=0.040)。干预2周后, 催产素组患者的针头-痛苦表情评分明显高于安慰剂组被试, 差异有统计学意义(t=2.33, P=0.022)。干预2周后, 催产素组的IRI总分(t=-2.58, P=0.011)及共情关心因子分(t=-3.15, P=0.002)均高于基线水平。干预后, 催产素组IRI总分(t=2.30, P=0.024)及观点采择因子分(t=2.57, P=0.012)均高于安慰剂组。结论催产素可改善男性品行障碍青少年的共情能力, 可能对认知及情感共情能力均有提高作用。Objective To investigate the effect of intranasal oxytocin administration on empathy in male adolescents with conduct disorder.Methods The male adolescents with conduct disorder in the Psychological Counseling Clinic of the Second Xiangya Hospital of Central South University from September 2015 to August 2016 were selected.And they were randomly assigned to oxytocin group(n=46)and placebo group(n=51)by random number table.Subjects in oxytocin group were given nasal spray of 24 IU oxytocin twice per day for two weeks,while those in placebo group were given nasal spray of 0.9%sodium chloride solution for two weeks.The empathy of patients was assessed with a pain-related empathy task and interpersonal reactivity index(IRI)before and after two weeks′administration.SPSS 20.0 software was used for statistical analysis,and repeated measurement analysis of variance was used to compare the empathy ability of the two groups before and after intervention.Results Repeated measurement analysis of variance showed that there were significant time×group interaction effects in the scores of painful expressions during the pain-related empathy task(F=13.86,P<0.001),IRI(F=5.59,P=0.020)and empathic concern subscale(F=4.99,P=0.028).There was significant between-group effect in the score of perspective-taking subscale of IRI(F=4.22,P=0.043).Simple effect analysis revealed that after two weeks of intervention,the score of needle-pain expression in oxytocin group was significantly higher than that at baseline(t=-2.08,P=0.040).And the score of needle-pain expression in oxytocin group was significantly higher than that in placebo group(t=2.33,P=0.022).After two weeks of intervention,the total IRI score(t=-2.58,P=0.011)and empathy factor score(t=-3.15,P=0.002)of oxytocin group were both higher than those at baseline.After intervention,the total IRI score(t=2.30,P=0.024)and perspective-taking factor score(t=2.57,P=0.012)in oxytocin group were higher than those in placebo group,and the differences were statistically significant.Conclusions

关 键 词：品行障碍 催产素 共情 青少年 

分 类 号：R749.94[医药卫生—神经病学与精神病学]