The effect of iron metabolism on anxiety disorder  

作　　者：Xingguang Li Xuerui Fu Wei Zhang Caipeng Cao Hongbo Shang Yongchuan Wang Tianyu Dong 

机构地区：[1]Yuanshi Hospital of traditional Chinese Medicine,Shijiazhuang 051130,China [2]Hebei Medical University,Shijiazhuang 050000,China

出　　处：《Journal of Translational Neuroscience》2020年第4期31-36,共6页转化神经科学电子杂志（英文）

摘　　要：Anxiety disorder is one of the most common emotional disorders,but its pathogenesis re-mains unclear.Research has shown that iron deficiency is more common in people with emotional disorders and that these disorders can improve after taking iron supple-ments.Many factors can cause anxiety disorders,includ-ing external stress,genetic factors,impaired neurodevel-opment,and abnormal monoamine metabolism.Studies have shown that abnormal monoamine metabolism and impaired neurodevelopment can contribute to the severity of emotional disorders.The synthesis of serotonin(5-HT)and dopamine(DA)require iron as a cofactor in the syn-thesis of monoamine metabolism,and the release of epi-nephrine(E)was potentially associated with labile iron in plasma.At the same time,iron is also directly involved in myelin synthesis as a cofactor in neural development.Therefore,iron maybe involved some of the main causes of the onset of anxiety disorders.

关 键 词：iron metabolism anxiety disorder NEURODEVELOPMENT synaptic plasticity MONOAMINE 

分 类 号：O62[理学—有机化学]