supported by funds from Fundacao para a Ciencia e a Tecnologia(FCT),Portugal,European Union,MCTES,and Fundo Social Europeu(FSE)in the scope of the Centro 2020 Regional Operational Programme(Carla’s PhD research grant 2021.06135;BD and Mariana’s PhD research grant 2020.6582.BD);supported by FCT Exploratory Project 2022.01066.PTDC,COMPETE and FEDER funds,FCT,Portugal.Figures 1 and 2 were created with BioRender.com.
Homeostasis of monoaminergic pathways is compromised in aging and neurodegenerative/neurological diseases such as Alzheimer’s disease and depression.On the other hand,their modulation has also been linked to the mech...
supported by grants to Yulong Li from the National Key R&DProgram of China(2019YFE011781);the National Natural Science Foundation of China(31925017 and 31871087);the NIH BRAIN Initiative(1U01NS113358 and 1U01NS120824);the Feng Foundation of Biomedical Research,the Clement and Xinxin Foundation,the Peking-TsinghuaCenter for Life Sciences,the State Key Laboratory of Membrane Biology at Peking University School of Life Sciences and the New Cornerstone Science Foundation through the New Cornerstone Investigator Program and the XPLORER PRIZE.
Octopamine(OA),analogous to norepinephrine in vertebrates,is an essentialmonoamine neurotransmitter in invertebrates that plays a significant role in various biological functions,including olfactory associative learni...
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040220);the National Natural Science Foundation of China(31671049,81773708,81072624,and 81173036);the National Key New Drug Creation Program of China(No.2017ZX09309012,2018ZX09739008,and 2018ZX09711002-002-012).
Hypidone hydrochloride(YL-0919)is a novel antidepressant in clinical phase II trial.Previous studies show that YL-0919 is a selective 5-HT(serotonin)reuptake inhibitor,5-HT1A receptor partial agonist,and 5-HT6 recepto...
This paper aims to examine theories that attempt to explain biochemical changes in the brain as well as the metabolism of individuals who experience symptoms and conditions related to neurological disorders like depre...
the National Natural Science Foundation of China(No.81673680)。
Objective To reveal the effect and mechanism of Jiaotai Pill(交泰丸,JTP)on insomniac rats.Methods The insomniac model was established by intraperitoneal injection of p-chlorophenylalanine(PCPA).In behavioral experimen...
Anxiety disorder is one of the most common emotional disorders,but its pathogenesis re-mains unclear.Research has shown that iron deficiency is more common in people with emotional disorders and that these disorders c...
supported by the National Natural Science Foundation of China(21801104,21871121,21431002);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2018QNRC001);the Fundamental Research Funds for the Central Universities of China(lzujbky-2019-sp01,lzujbky-2019-kb12);the Special Fund Project of Guiding Scientific and Technological Innovation Development of Gansu Province(2019ZX-04);support by the US Department of Energy(DE-FG02-07ER46427);support of Gansu Computing Center of China。
Inhibiting the irreversible escape of organic cations and iodide species in perovskite films is crucial for the fabrication of efficient and stable perovskite solar cells(PSCs).Here,we develop a reaction-and-assembly ...
Objective:To study the effects of Schisandra B on neurotransmitter content,inflammation and oxidative stress in the hippocampus of depression model rats.Methods:A total of 30 male SD rats were randomly divided into th...
The expected growth of the elderly population at highest risk for Parkinson’s disease(PD)in the next decades makes the identification of factors that promote or prevent the disease an important goal.In addition,new t...
Objective:To investigate the effects of routine rehabilitation therapy combined with low frequency head stimulation on monoamine neurotransmitters, neuron-specific enolase (NSE), endothelin-1 (ET-1) and cerebral hemod...