SCHISANDRIN

作品数：12被引量：46H指数：4
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相关领域：医药卫生更多>>
相关作者：许银燕徐青更多>>
相关机构：淮安市妇幼保健院南京医科大学更多>>
相关期刊：《长春中医药大学学报》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors被引量：5
《Acta Pharmaceutica Sinica B》2023年第6期2765-2777,共13页Lijuan Ma Boyi Li Jinchen Ma Chunyuan Wu Nan Li Kailin Zhou Yun Yan Mingshuang Li Xiaoyan Hu Hao Yan Qi Wang Yanfei Zheng Zhisheng Wu 
co-supported by National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(No.82022073);National Natural Science Foundation of China(No.82174389);Natural Science Foundation of Beijing Municipality(No.7202115,China);Postdoctoral Research Foundation of China(No.2021M690474)。
Oligoasthenospermia is the primary cause of infertility.However,there are still enormous challenges in the screening of critical candidates and targets of oligoasthenospermia owing to its complex mechanism.In this stu...
关键词：OLIGOASTHENOSPERMIA Male infertility AUTOPHAGY APOPTOSIS BIOSENSOR Schisandrin A. 
Chemoproteomics identifies Ykt6 as the direct target of schisandrin A for neuroprotection
《Chinese Chemical Letters》2023年第6期401-405,共5页Tiantian Wang Yu Zhou Hao Zheng Tao Shen Dongmei Wang Jinlan Zhang 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS,Nos.2021-I2M-1-069,2022-12M-2-002);Beijing Municipal Natural Science Foundation,China(No.7222259)。
Schisandrin A is a natural dibenzocyclooctene lignan with potent neuroprotective activity.However,the specific mechanisms or direct target proteins have not been clarified up to now.In this study,we designed and synth...
关键词：Schisandrin A Activity-based protein profiling(ABPP) NEUROPROTECTION Ykt6 AUTOPHAGY 
Effects of Schisandra B on neurotransmitter contents, inflammation and oxidative stress in hippocampus of depression model rats
《Journal of Hainan Medical University》2019年第15期5-9,共5页Xiao-Jun Cai Yan-Peng Xie Zhen-Hua Lu Yang Hu Lei Wang Xiao-Yun Zhang SongLiu Xu-Ling Wang 
Objective:To study the effects of Schisandra B on neurotransmitter content,inflammation and oxidative stress in the hippocampus of depression model rats.Methods:A total of 30 male SD rats were randomly divided into th...
关键词：Depression SCHISANDRIN B MONOAMINE NEUROTRANSMITTERS Inflammatory RESPONSE Oxidative stress RESPONSE 
Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling被引量：3
《Chinese Journal of Natural Medicines》2018年第12期916-925,共10页WANG Jia-Wei LIANG Feng-Yin OUYANG Xiang-Shuo LI Pei-Bo PEI Zhong SU Wei-Wei 
supported by Guangzhou Clinical Research and Translational Centre for Major Neurological Diseases(No.201604020010);Natural Science Foundation of Guangdong Province(No.2015A030310255)
Schisandra chinensis, a traditional Chinese medicine(TCM), has been used to treat sleep disorders. Zebrafish sleep/wake behavioral profiling provides a high-throughput platform to screen chemicals, but has never been ...
关键词：Traditional Chinese medicine SCHISANDRA CHINENSIS Zebrafish Behavior PROFILING NEUROTRANSMITTER 
Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice： involvement of adjusting neurotransmitters and their metabolite changes in the brain被引量：11
《Acta Pharmacologica Sinica》2018年第4期616-625,共10页Bin-bin WEI Ming-yan LIU Zai-xing CHEN Min-jie WEI 
Neurotransmitters （NTs） in the brain are involved in neurodegenerative diseases, such as Alzheimer’s disease （AD）. Schisandrin is a major ingredient of Schisandra chinensis （Turcz.） Baill and has been used for ...
关键词：Alzheimer＇s disease APP/PS1 transgenic mice SCHISANDRIN learning and memory Aβ deposition NEUROTRANSMITTERS UPLC-MS/MS 
Investigation of in Vitro and in Vivo Metabolism of Schisandrin B from Schisandrae Fructus by Liquid Chromatography Coupled Electrospray Ionization Tandem Mass Spectrometry被引量：1
《Pharmacology & Pharmacy》2015年第8期363-373,共11页Tianxiu Qian Pou Kuan Leong Kam Ming Ko Wan Chan 
Schisandrin B (Sch B) is one of the active dibenzocyclooctadiene lignans found in the Schisandrae Fructus. Experimental studies have shown that Sch B possesses various pharmacological properties, including anti-cancer...
关键词：SCHISANDRIN B METABOLISM DISPOSITION UPLC-MS/MS 
五味子乙素对人卵巢癌Skov3细胞株的增殖、凋亡及Wnt／β-catenin信号通路的影响被引量：12
《临床肿瘤学杂志》2014年第7期589-593,共5页曾雯琼 徐青 许银燕 
目的探讨五味子乙素(Sch B)对人卵巢癌Skov3细胞株的增殖、凋亡及Wnt/β-catenin信号通路的影响。方法采用0、1.0、10.0、20.0、50.0μmol/L Sch B处理Skov3细胞,采用四甲基偶氮唑盐(MTT)法检测各浓度处理24、48、72和96h的增殖抑制率,A...
关键词：SCHISANDRIN B 卵巢癌 增殖 凋亡 WNT Β-CATENIN信号通路 
Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease被引量：12
《Chinese Journal of Natural Medicines》2014年第4期251-258,共8页LV Yan-Ni LI Shao-Xia ZHAI Ke-Feng KOU Jun-Ping YU Bo-Yang 
supported by the National Natural Science Foundation of China(No.81274004);National Key Technologies R&D Program of China(No.2008BAI51B03);2011’Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education,a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Project Program of the State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.JKGZ201107);the Graduate Student Scientific Research Innovation Plan of Jiangsu Higher Education Institutions(No.CXZZ11_0795)
AIM： To illuminate the molecular targets for schisandrin against cerebrovascular disease based on the combined methods of network pharmacology prediction and experimental verification. METHOD： A protein database was...
关键词：SCHISANDRIN Network pharmacology Cerebrovascular disease Molecular target NF-xB signaling pathway 
The Sensitization of Anti-Cancer Therapy by Squalene and Schisandrin Through the Modulation of DNA Damage Checkpoint Activity.被引量：1
《长春中医药大学学报》2008年第5期601-601,共1页HiroshiNishida NaotoTatewaki YukiNakajima TetsuyaKonishi NobuoIkekawa 
ATM(ataxia telangiectasia mutated)and ATR(AT and Rad3 related)protein kinases play a crucial role in cellular DNA damage responses.The inhibition of these kinases and/or following effectors lead to an abolishment of o...
关键词：五味子 DNA损伤 中医 肿瘤 治疗方法 
Study on HPLC method to determine contents of Schisandrin A and Schisandrin B in Schisandra chinensis extraction
《Journal of Northeast Agricultural University(English Edition)》2007年第4期323-326,共4页XU Liangmei LI Jianping YAN Changjiang SHAN Anshan 
Supported by National Basic Research Program of China(2004CB11750-5)
The determination method of Schisandrin A and Schisandrin B in Schisandra chinensis was improved with the high performance liquid chromagraphy （HPLC）. The sample was extracted exceedingly in the critical limit of CO...
关键词：HPLC Schisandra chinensis Schisandra A Schisandrin B 
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