Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects  

作　　者：Yonghui Qiao Zhihao Wei Tingting Qin Rufeng Song Zhiqiang Yu Qi Yuan Juan Du Qingbing Zeng Lanlan Zong Shaofeng Duan Xiaohui Pu 

机构地区：[1]Henan University of Chinese Medicine,Zhengzhou 450046,China [2]Institute of Pharmacy,School of Pharmacy,Henan University,Kaifeng 475004,China [3]School of Pharmaceutics Sciences,Southern Medical University,Guangzhou 510515,China [4]Department of Pharmacy,The Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,China

出　　处：《Chinese Chemical Letters》2021年第9期2877-2881,共5页中国化学快报（英文版）

基　　金：supported by Leading Talents Program of Zhongyuan Science and Technology Innovation(No.204200510022);Program for Innovative Research Team(in Science and Technology)in University of Henan Province(No.21IRTSTHN026);Henan Provincial Key Research-Development and Special Project For Promotion(Nos.192102310030,202102310483);Kaifeng Science and Technology Development Plan Project and the Key Project of Science(Nos.1903034,1908006);the Key Project of Science and Technology Research funded by the Henan Provincial Department of Education(No.19A350001)。

摘　　要：Tumor drug resistance and systemic side effects of chemotherapeutic drugs are the main reasons for the failure of cancer treatment.In recent years,it was found that some natural active ingredients can reverse MDR and regulate body immunity to enhance the efficacy and reduce toxicity of chemotherapeutic drugs.In this paper,a new nanosuspensions,HCPT and QUR hybrid nanosuspensions(HQ-NPs),was prepared by the microprecipitation-high pressure homogenization method to reverse tumor drug resistance,reduce toxicity,and increase therapeutic efficacy.The in vitro investigation results showed that HQ-NPs had a unique shape(particle size was about 216.3±5.9 nm),changed crystalline,and different dissolution rates compared with HCPT-NPs and QUR-NPs,which is attributed to the strong intermolecular forces between HCPT and QUR as indicated by the results of the molecule dock.It was verified that the HQ-NPs could double the retention of HCPT in cells and enhance the cytotoxicity to A549/PTX cells in vitro tests compared with HCPT-NPs.We also found that HQ-NPs can significantly enhance the accumulation of HCPT in tumor sites,improve the antitumor activity of HCPT,and protect the immune organs and other normal tissues(P<0.01),compared with HCPT-NPs.Therefore,hybrid nanosuspensions can offer promising potential as the drug delivery system for HCPT and QUR to increase the therapeutic efficacy and reduce the toxicity of HCPT.

关 键 词：Combination therapy Multidrug resistance NANOSUSPENSIONS Antitumor activity IMMUNOMODULATORY 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R943[医药卫生—药剂学]