Rarely fast progressive memory loss diagnosed as Creutzfeldt-Jakob disease:A case report  

作　　者：Yong-Wei Xu Jie-Qun Wang Wei Zhang Shu-Chang Xu Yun-Xia Li 

机构地区：[1]Department of Gastroenterology,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China [2]Department of Neurology,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China

出　　处：《World Journal of Clinical Cases》2021年第34期10638-10644,共7页世界临床病例杂志

基　　金：Shanghai Shenkang Hospital Development Center,No.SHDC12016109.

摘　　要：BACKGROUND Creutzfeldt-Jakob disease(CJD)is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia.It almost always results in death within 1-2 years from symptom onset.CASE SUMMARY Here,we report the case of a 57-year-old male who initially experienced dizziness followed by a 1-mo fast decline in memory function.He presented to the local hospital and underwent magnetic resonance imaging and cerebrospinal fluid(CSF)examination,with no definitive diagnosis.However,the symptoms of progressive forgetting worsened.In addition,he exhibited progressive involuntary tremor of the limbs.Then,he came to our hospital,and according to the results of CSF examination,electroencephalography(EEG)and magnetic resonance imaging(MRI)tests and clinical manifestations of cerebellar ataxia,dementia,and myoclonus that rapidly progressed,with a short duration of illness,he was finally diagnosed with sporadic CJD(sCJD).CONCLUSION This case report aims to create awareness among physicians to emphasize auxiliary examination,CSF examination,EEG and MRI tests and recognition of cerebellar ataxia,dementia,and myoclonus that rapidly progress to prompt pursuit of an early diagnosis and identification of sCJD and to reduce complications.

关 键 词：Creutzfeldt-Jakob disease Prion disorders Progressive memory loss DEMENTIA Case report 

分 类 号：R741[医药卫生—神经病学与精神病学]