Why stem/progenitor cells lose their regenerative potential  

作　　者：Angela Picerno Alessandra Stasi Rossana Franzin Claudia Curci Ighli di Bari Loreto Gesualdo Fabio Sallustio 

机构地区：[1]Department of Emergency and Organ Transplantation,University of Bari“Aldo Moro”,Bari 70124,Italy [2]Department of Interdisciplinary Medicine,University of Bari“Aldo Moro”,Bari 70124,Italy

出　　处：《World Journal of Stem Cells》2021年第11期1714-1732,共19页世界干细胞杂志（英文版）（电子版）

摘　　要：Nowadays,it is clear that adult stem cells,also called as tissue stem cells,play a central role to repair and maintain the tissue in which they reside by their selfrenewal ability and capacity of differentiating into distinct and specialized cells.As stem cells age,their renewal ability declines and their capacity to maintain organ homeostasis and regeneration is impaired.From a molecular perspective,these changes in stem cells properties can be due to several types of cell intrinsic injury and DNA aberrant alteration(i.e epigenomic profile)as well as changes in the tissue microenviroment,both into the niche and by systemic circulating factors.Strikingly,it has been suggested that aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various agingassociated disorders.Therefore,understanding how resident stem cell age and affects near and distant tissues is fundamental.Here,we examine the current knowledge about aging mechanisms in several kinds of adult stem cells under physiological and pathological conditions and the principal aging-related changes in number,function and phenotype that determine the loss of tissue renewal properties.Furthermore,we examine the possible cell rejuvenation strategies.Stem cell rejuvenation may reverse the aging phenotype and the discovery of effective methods for inducing and differentiating pluripotent stem cells for cell replacement therapies could open up new possibilities for treating age-related diseases.

关 键 词：Stem cells AGING SELF-RENEWAL REJUVENATION Aging-associated disorders Epigenetic changes Aging environment 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]