Transmembrane serine protease 2 and angiotensin-converting enzyme 2 anti-inflammatory receptors for COVID-19/inflammatory bowel diseases treatment  

作　　者：Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Amir Hossein Abdolghaffari 

机构地区：[1]Department of Toxicology and Pharmacology,Faculty of Pharmacy,Tehran Medical Sciences,Islamic Azad University,Tehran 1941933111,Iran [2]Medicinal Plants Research Center,Institute of Medicinal Plants,ACECR,Karaj 141554364,Iran [3]Toxicology and Diseases Group(TDG),Pharmaceutical Sciences Research Center(PSRC),The Institute of Pharmaceutical Sciences(TIPS),Tehran University of Medical Sciences,Tehran 1941933111,Iran [4]Department of Toxicology and Pharmacology,Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran 1941933111,Iran [5]Gastrointestinal Pharmacology Interest Group(GPIG),Universal Scientific Education and Research Network(USERN),Tehran 1941933111,Iran

出　　处：《World Journal of Gastroenterology》2021年第46期7943-7955,共13页世界胃肠病学杂志（英文版）

摘　　要：long-term,and relapsing inflammatory disorders.IBD may spontaneously grow in the colon,and in severe cases may result in tumor lesions such as invasive carcinoma in inflamed regions of the intestine.Recent epidemiological reports indicate that old age and underlying diseases such as IBD contribute to severity and mortality in patients with coronavirus disease 2019(COVID-19).Currently,the ongoing COVID-19 pandemic caused serious morbidity and mortality worldwide.It has also been shown that the transmembrane serine protease 2 is an essential factor for viral activation and viral engulfment.Generally,viral entry causes a'cytokine storm'that induces excessive generation of proinflammatory cytokines/chemokines including interleukin(IL)-6,IL-2,IL-7,tumor necrosis factor-α,and interferon-γ.Future research could concentrate on developing inflammatory immunological responses that are efficient to encounter COVID-19.Current analysis elucidates the role of inflammation and immune responses during IBD infection with COVID-19 and provides a list of possible targets for IBD-regulated therapies in particular.Data from clinical,in vitro,and in vivo studies were collected in English from PubMed,Google Scholar,Scopus,and the Cochrane library until May 2021.

关 键 词：Inflammatory bowel diseases COVID-19 Transmembrane serine protease 2 INFLAMMATION PRO-INFLAMMATORY Immunological responses 

分 类 号：R563.1[医药卫生—呼吸系统] R574[医药卫生—内科学]