Multifaceted roles of centrosomes in development,health,and disease  

作　　者：Feifei Qi Jun Zhou 

机构地区：[1]Institute of Biomedical Sciences,College of Life Sciences,Shandong Normal University,Jinan 250014,China [2]State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China

出　　处：《Journal of Molecular Cell Biology》2021年第9期611-621,共11页分子细胞生物学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(31730050 and 32000481).

摘　　要：The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells.The past decades have witnessed the functional complexity and importance of centrosomes in various cellular processes such as cell shaping,division,and migration.In addition,centrosome abnormalities are linked to a wide range of human diseases and pathological states,such as cancer,reproductive disorder,brain disease,and ciliopathies.Herein,we discuss various functions of centrosomes in development and health,with an emphasis on their roles in germ cells,stem cells,and immune responses.We also discuss how centrosome dysfunctions are involved in diseases.A better understanding of the mechanisms regulating centrosome functions may lead the way to potential therapeutic targeting of this organelle in disease treatment.

关 键 词：CENTROSOME germ cell stem cell IMMUNITY ciliopathy Introduction 

分 类 号：Q25[生物学—细胞生物学]