帕金森病患者血压昼夜节律紊乱的研究进展  

Circadian rhythm disorder of blood pressure in Parkinson′s disease

作　　者：肖仁清 万赢[1] 刘振国[1] Xiao Renqing;Wan Ying;Liu Zhenguo(Department of Neurology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院神经内科,200092

出　　处：《中华神经科杂志》2021年第12期1307-1311,共5页Chinese Journal of Neurology

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(2017YFC1310300);国家自然科学基金(81771211,81703852);上海市科学技术委员会生物医药领域科技支撑项目(17401901000,19401932100);上海市综合医院中西医结合专项(ZHYY-ZXYJHZX-202021)。

摘　　要：血压昼夜节律紊乱是帕金森病患者常见的血压异常形式,包括血压昼夜模式异常、夜间高血压、血压变异性增高和觉醒低血压4种类型。帕金森病伴发血压昼夜节律紊乱的发生机制复杂,涉及生物节律紊乱、心血管功能障碍、激素分泌紊乱和睡眠-觉醒周期及结构的破坏,同时受到昼夜活动模式、情绪、抗帕金森病药物等多种因素的影响。研究结果表明,血压昼夜节律紊乱与帕金森病临床表型、疾病进展和预后关系密切。加强对帕金森病患者血压昼夜节律紊乱的筛查和干预,有助于优化帕金森病临床干预策略,提高患者生活质量。Circadian rhythm disorder of blood pressure is a common abnormal form of blood pressure in Parkinson′s disease,including abnormal circadian blood pressure pattern,nocturnal hypertension,increased blood pressure variability and awakening hypotension.The pathogenesis of circadian rhythm disorder of blood pressure in Parkinson′s disease is complex,which involves the disruption of circadian rhythm,cardiovascular dysfunction,abnormal hormone secretion and the disorders of sleep-wake cycle and structure.At the same time,it is affected by many factors such as circadian activity rhythm,emotion,anti-Parkinson′s disease drugs and so on.Studies have shown that the circadian rhythm disturbance of blood pressure is closely related to the clinical phenotypes,progression and prognosis of Parkinson′s disease.Therefore,it is suggested to enhance the screening and intervention of circadian rhythm disorders of blood pressure to optimize treatment and improve quality of life in Parkinson′s disease.

关 键 词：帕金森病 血压 昼夜节律 发病机制 临床表型 干预 

分 类 号：R742.5[医药卫生—神经病学与精神病学]