7,8-氧-苄基-4-氧-烯丙基-Kdo烯糖受体的合成  

Synthesis of methyl 4-O-allyl-2,6-anhydro-7,8-O-benzyl-3-deoxy-D-manno-oct-2-ennoate

作　　者：徐成英 杨劲松[1] XU Chenying;YANG Jinsong(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China)

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2021年第6期607-609,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:21772132)。

摘　　要：目的制备7,8-氧-苄基-4-氧-烯丙基-Kdo烯糖受体。方法以草酰乙酸和D-阿拉伯糖为起始原料,制备化合物Ⅺ,再通过异亚丙基化、烯糖化、苄基化、烯丙基化等7步反应,制得目标化合物Ⅰ。结果与结论目标化合物的结构经;HNMR、;CNMR及HRMS(ESI)确证。该化合物为鲍曼不动杆菌脂多糖寡糖片段的合成奠定了基础。OBJECTIVE To synthesize methyl 4-O-allyl-2,6-anhydro-7,8-O-benzyl-3-deoxy-D-manno-oct-2-ennoate.METHODS Oxaloacetic acid and D-arabinose were adopted as starting materials, and compound Ⅺ was prepared.The target product Ⅰ was synthesized from compound Ⅺ through 7-step reactions including isopropylation, englycosylation, benzylation, and allylation.RESULTS The structure was confirmed by;HNMR,;CNMR and HRMS(ESI).CONCLUSION This compound has laid a foundation for the synthesis of LPS oligosaccharide fragments of Acinetobacter baumannii.

关 键 词：糖化学 3-去氧-D-甘露-2-辛酮酸 烯糖 设计 合成 保护基 受体 

分 类 号：R914[医药卫生—药物化学]