Hot Topics in Recent Parkinson’s Disease Research:Where We are and Where We Should Go  

作　　者：Song Li Congcong Jia Tianbai Li Weidong Le 

机构地区：[1]Liaoning Provincial Center for Clinical Research on Neurological Diseases,The First Affiliated Hospital,Dalian Medical University,Dalian 116021,China [2]Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases,The First Affiliated Hospital,Dalian Medical University,Dalian 116021,China [3]Institute of Neurology,Sichuan Academy of Medical Sciences,Sichuan Provincial People’s Hospital,Medical School of the University of Electronic Science and Technology of China,Chengdu 610072,China

出　　处：《Neuroscience Bulletin》2021年第12期1735-1744,共10页神经科学通报（英文版）

基　　金：the National Key Research and Development Program of China(2016YFC1306600);the National Natural Science Foundation of China(82001483);the Guangdong Provincial Key R&D Program(2018B030337001).

摘　　要：Parkinson’s disease(PD),the second most common neurodegenerative disease,is clinically characterized by both motor and non-motor symptoms.Although overall great achievements have been made in elucidating the etiology and pathogenesis of PD,the exact mechanisms of this complicated systemic disease are still far from being clearly understood.Consequently,most of the currentlyused diagnostic tools and therapeutic options for PD are symptomatic.In this perspective review,we highlight the hot topics in recent PD research for both clinicians and researchers.Some of these hot topics,such as sleep disorders and gut symptoms,have been neglected but are currently emphasized due to their close association with PD.Following these research directions in future PD research may help understand the nature of the disease and facilitate the discovery of new strategies for the diagnosis and therapy of PD.

关 键 词：Parkinson’s disease Gut-brain axis Biomarkers NEUROINFLAMMATION Sleep disorder Genetics Ferroptosis 

分 类 号：R742.5[医药卫生—神经病学与精神病学]