Adaptation of mammals to hypoxia  

作　　者：Fang Li Zhenglei Qiao Qijiao Duan Eviatar Nevo 

机构地区：[1]College of Life Sciences and Technology,Mudanjiang Normal University,Mudanjiang,China [2]College of Natural Resources and Environment,South China Agriculture University,Guangzhou,China [3]Institute of Evolution,University of Haifa,Haifa,Israel

出　　处：《Animal Models and Experimental Medicine》2021年第4期311-318,共8页动物模型与实验医学（英文）

基　　金：Doctoral Research Fund of Mudanjiang Teachers College,Grant/Award Number:No.1002319042;The filing project of Heilongjiang Education Department,Grant/Award Number:1354MSYTD024;Ancell-Teicher Research Foundation for Genetic and Molecular Evolution.

摘　　要：Oxygen plays a pivotal role in the metabolism and activities of mammals.However,oxygen is restricted in some environments-subterranean burrow systems or habitats at high altitude or deep in the ocean-and this could exert hypoxic stresses such as oxidative damage on organisms living in these environments.In order to cope with these stresses,organisms have evolved specific strategies to adapt to hypoxia,including changes in physiology,gene expression regulation,and genetic mutations.Here,we review how mammals have adapted to the three high-altitude plateaus of the world,the limited oxygen dissolved in deep water habitats,and underground tunnels,with the aim of better understanding the adaptation of mammals to hypoxia.

关 键 词：HEMOGLOBIN HIGH-ALTITUDE HYPOXIA marine mammals subterranean mammals 

分 类 号：R594.3[医药卫生—内科学] R-332[医药卫生—临床医学]