Role of oxidative stress in anti-cancer activity of Tripterygium wilfordii  

作　　者：Li-Ping Yang Jian Hao Dan Chen 

机构地区：[1]Department of Pharmacy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application(Beijing Hospital),Beijing 100730,China [2]TMR Publishing Group,Auckland 2014,New Zealand

出　　处：《Traditional Medicine Research》2021年第6期3-7,共5页TMR传统医学研究

摘　　要：Introduction Oxidative stress,a characteristic of tumor cells,is defined as a relative excess of reactive oxygen species(ROS),directly associated with cancer.Although excessive ROS can cause oxidative damage,ROS within a certain threshold range can play an important second messenger function and participate in regulating important signaling pathways in cells,including induction of autophagy and apoptosis.Research has shown that acute and high ROS concentrations can damage DNA and induce cell apoptosis,whereas moderate ROS concentrations can induce temporary or permanent cell cycle arrest and cell differentiation.

关 键 词：DAMAGE TRIPTERYGIUM ACUTE 

分 类 号：R73[医药卫生—肿瘤]