卒中后抑郁的神经生物学机制  

Neurobiological mechanism of post-stroke depression

作　　者：邢艳 张彦妹[1] 刘亚婷 郑乃智[1] Yan Xing;Yanmei Zhang;Yating Liu;Naizhi Zheng(Department of Neurology,Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266011,China;Weifang Medical University,Weifang 261053,China)

机构地区：[1]青岛大学附属青岛市市立医院神经内科,266011 [2]潍坊医学院,261053

出　　处：《国际脑血管病杂志》2021年第10期785-788,共4页International Journal of Cerebrovascular Diseases

摘　　要：卒中后抑郁是卒中常见的并发症之一,可严重影响卒中患者的功能康复,增高卒中患者的病死率和残疾率。关于卒中后抑郁的发病机制,内源性学说强调与生物学机制密切相关,反应性学说则认为与心理社会因素有关。目前卒中后抑郁发病机制及治疗的研究重点集中在炎症、免疫反应、应激、神经再生、脑网络、生物节律紊乱、睡眠障碍、褪黑素等方面。文章就卒中后抑郁的神经生物学机制研究进展及及针对发病机制的相关治疗进行了综述。Post-stroke depression(PSD)is one of the common complications of stroke,which can seriously affect the functional rehabilitation of patients with stroke and increase their mortality and disability rate.As for the pathogenesis of PSD,endogenous theory emphasizes that it is closely associated with biological mechanism,while reactive theory believes that it is associated with psychosocial factors.At present,the research on the pathogenesis and treatment of PSD focuses on inflammation,immune response,stress,nerve regeneration,brain network,biological rhythm disorder,sleep disorder,melatonin and so on.This article reviews the research progress on the neurobiological mechanism of PSD and the related treatment for the pathogenesis.

关 键 词：卒中 抑郁症 神经生物学 神经免疫调节 神经元可塑性 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]